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Новости за 25.11.2024

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Validation of the biological function and prognostic significance of AURKA in neuroblastoma

Plos.org 
En

by Jing Chu

Background

Neuroblastoma (NB) is the most common extracranial solid tumor in children, and the AURKA gene encodes a protein kinase involved in cell cycle regulation that plays an oncogenic role in a variety of human cancers. The aim of this study was to validate the biological function and prognostic significance of AURKA in NB using basic experiments and bioinformatics.

Methods

Data obtained from Target and GEO databases were analyzed using various bioinformatic techniques. Читать дальше...



Fatigue and cognitive dysfunction in previously hospitalized patients with COVID-19: A 1-year follow-up

Plos.org 
En

by Ingrid Andreasson, Hanna C. Persson, Ann Björkdahl

Purpose

The aim was to longitudinally explore changes in fatigue- and cognition-related symptoms during the first year after hospital treatment for COVID-19.

Method

Patients hospitalized for COVID-19 in Gothenburg, Sweden, were consecutively included from 01-07-2020 to 28-02-2021. Patients were assessed at the hospital (acute) and at 3 and 12 months after hospital discharge. Cognition was assessed with the Montreal Cognitive Assessment (MoCA)... Читать дальше...

Extraction of clinical data on major pulmonary diseases from unstructured radiologic reports using a large language model

Plos.org 
En

by Hyung Jun Park, Jin-Young Huh, Ganghee Chae, Myeong Geun Choi

Despite significant strides in big data technology, extracting information from unstructured clinical data remains a formidable challenge. This study investigated the utility of large language models (LLMs) for extracting clinical data from unstructured radiological reports without additional training. In this retrospective study, 1800 radiologic reports, 600 from each of the three university hospitals, were collected, with seven pulmonary outcomes defined. Читать дальше...

Predicting long-term functional anti-VEGF treatment outcomes in neovascular AMD in a real-world setting

Plos.org 
En

by Isabel B. Pfister, Christin Schild, Justus G. Garweg

Purpose

To test to what degree retinal fluid (RF) after the loading phase and at the end of year 1 predicts long-term functional outcomes in neovascular macular degeneration (nAMD), as do macular (MA) atrophy, treatment density and treatment interval extension.

Methods

In this retrospective single-center cohort study, a consecutive series of eyes with treatment-naïve nAMD followed under a treat-and-extend (T&E) protocol followed over ≥2 years. Читать дальше...

Non-pharmaceutical interventions for people living with HIV with cognitive impairment: A scoping review

Plos.org 
En

by Lucinda Stuart, Kate Alford, Jamie H. Vera

Background

Cognitive impairment (CI) in HIV is often of multifactorial causation, and remains a prominent issue in the age of effective combination antiretroviral therapy (cART), affecting approximately 14% of people living with HIV. Despite the 2018 BHIVA directive stating the importance of commencing rehabilitation strategies in people living with HIV with CI, no types of cognitive rehabilitations or other non-pharmaceutical interventions are specifically recommended. Читать дальше...

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Москва

Сеть ресторанов "Грильница" открыла первый ресторан в Московской области


Determinants of depression among ever-married adolescent girls in Bangladesh: Evidence from the Bangladesh Adolescent Health and Wellbeing Survey 2019–2020

Plos.org 
En

by Mehedi Hasan, Md Al Amin

Background

Common mental health disorders in early life represent a major challenge and these conditions become more complicated and substantial during the development period of adolescence. Despite the global concern over the increasing prevalence of mental health issues among adolescents, it remains largely a neglected area of research and health policy in Bangladesh, where the burden of child marriage is significantly higher. This study aimed to investigate... Читать дальше...

Unsupervised classification of Blanding’s turtle (Emydoidea blandingii) behavioural states from multi-sensor biologger data

Plos.org 
En

by Kelton Adderley-Heron, Patricia Chow-Fraser

Classifying animal behaviors in their natural environments is both challenging and ecologically important, but the use of biologgers with multiple sensors has significantly advanced this research beyond the capabilities of traditional methods alone. Here, we show how biologgers containing an integrated tri-axial accelerometer, GPS logger and immersion sensor were used to infer behavioural states of a cryptic, freshwater turtle, the Blanding’s turtle (Emydoidea blandingii). Читать дальше...


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