Loss of Notch dimerization perturbs intestinal homeostasis by a mechanism involving HDAC activity
by Quanhui Dai, Kristina Preusse, Danni Yu, Rhett A. Kovall, Konrad Thorner, Xinhua Lin, Raphael Kopan
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by Quanhui Dai, Kristina Preusse, Danni Yu, Rhett A. Kovall, Konrad Thorner, Xinhua Lin, Raphael Kopan
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by Abigail O. Smith, William Tyler Frantz, Kenley M. Preval, Yvonne J. K. Edwards, Craig J. Ceol, Julie A. Jonassen, Gregory J. Pazour
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by Atle E. Rimehaug, Anders M. Dale, Anton Arkhipov, Gaute T. Einevoll
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by Nathan R. Zuniga, Noah E. Earls, Ariel E. A. Denos, Jared M. Elison, Benjamin S. Jones, Ethan G. Smith, Noah G. Moran, Katie L. Broce, Gerome M. Romero, Chad D. Hyer, Kimberly B. Wagstaff, Haifa M. Almughamsi, Mark K. Transtrum, John C. Price
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by Yutong Sun, Peng Qiu
When analyzing scRNA-seq data containing heterogeneous cell populations, an important task is to select informative marker genes to distinguish various cell clusters and annotate the clusters with biologically meaningful cell types. In existing analysis methods and pipelines, marker genes are typically identified using a one-vs-all strategy, examining differential expression between one cell cluster versus the combination of all other cell clusters. However, this strategy... Читать дальше...
by Montserrat Llanses Martinez, Keqian Nan, Zhe Bao, Rachele Bacchetti, Shengnan Yuan, Joe Tyler, Xavier Le Guezennec, Frederic A. Bard, Elena Rainero
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Conagra Brands is adding “GLP-1 friendly” to packaging on Healthy Choice frozen meals to woo users of weight-loss drugs.
Check out why even with a nearly full moon, you may still be able to see this meteor shower.
The third matchup in two weeks between the Heat and Raptors
The post Gameday: Raptors @ Heat, December 12 first appeared on Raptors Republic.
The variations of locators are: knob style identified as CP723; adjustable handle style as CP722; cam handle style as CP731 and hex-head style asCP730.
Ruby Augustine may be 105 years old, but that hasn't stopped her from climbing the stairs every day — something she challenges every visitor to do as well.
Video: 00:01:22
On 9 December 2024, the Smile Platform arrived safely at Amsterdam Schiphol airport and was subsequently transported to ESA's European Space Research and Technology Centre (ESTEC) in Noordwijk, the Netherlands. It came a long way, having travelled all the way from Shanghai, China.
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They could store 15,000 times more energy than steel springs and three times more energy than lithium.
IP Copilot raises $4.2M to transform enterprise patent discovery with AI technology that monitors workplace communications and identifies patentable innovations in real time, helping companies build stronger IP portfolios.
Cooldown Games announced its launch as a publisher of independent games for PC and console, with focus on games that fit in a busy lifestyle.
Have you ever felt better after singing in the show? Well, serial game entrepreneur Mike Wilson thinks you'll feel better singing in virtual reality.
The Boy Who Lived rises again for HBO's 'Harry Potter,' but this is an unnecessary TV show that's heading straight toward disaster.
In more ways than one, today’s Total War: Warhammer 3 expansion marks a milestone for game director Rich Aldridge and his team at Creative Assembly. Omens Of Destruction’s three headline legendary lords each bring new campaigns and units for their respective factions, but it’s the fourth lord - a Khorne champion free to all players - that I imagine Aldridge will end up remembering the most fondly.
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They call him Kraven the Hunter, but he could go by many names.
Kraven the Unnecessary.
Kraven the Forgettable.
Kraven the Dud.
Despite the presence of a charismatic leading man, two Academy Award winners in key supporting roles and a director of substance, “Kraven the Hunter” is another giant swing-and-a-miss for Sony Pictures' stand-alone Spider-Man villain roster, following the “Venom” trilogy, “Morbius” and “Madame Web.” (That’s a lineup so weak it makes the historically... Читать дальше...
Stay ahead in tech with the CompTIA Super Bundle.
Twenty-five years after starring in ‘The End of the Affair,’ the leads of ‘The Room Next Door’ and ‘Conclave’ open up about their friendship, the joy they take in acting, and why Fiennes spent his post-’Conclave’ months “hair growing and getting ripped.”
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It’s time to talk about those ugly stains in your toilet. (No, not those ones.) We mean those rust-colored ones that show up at the water line in the form of rings of discoloration. They’re caused by hard water and mineral deposits, and they’re exceptionally hard to get rid of — unless you have a Krazy Klean Pro…
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If you’re reading Jalopnik, you’re likely a car aficionado (and/or nerd), and thus likely to know more about cars than the average bear. If you know cars, then you know that they’re incredibly complex machines with thousands of moving parts. Beyond the mechanics of it all lies the somehow more complex and…
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