Covalent fragment-based lead discovery is becoming ever more popular, driven by success against difficult targets such as KRASG12C. These efforts require the design of new libraries, and in a recent J. Med. Chem. paper Simon Lucas and colleagues at AstraZeneca describe their design philosophy. (Co-author Henry Blackwell presented some of this work at the CHI FBLD meeting earlier this year.)
Читать дальше...
Play as Michael Scott, Dwight, Jim and Pam in Funko Fusion's newest pop culture crossover.
DANNY Dyer has broken his silence on a potential return to EastEnders – and revealed how he rowed with bosses over a Christmas Day suicide plot.
Читать дальше...
The jungle is set to undergo massive changes.
The decline in Eurozone’s largest economy is threatening to become irreversible and send ripples across the EU, the outlet has warned
Read Full Article at RT.com
The decline is threatening to become irreversible, the outlet has warned
Читать дальше...Schools could soon change for students in Dripping Springs Independent School District as the school board considers moving forward with new boundary attendance zones.
House Republican Rep. Andrew Clyde, R-Ga., is leading the charge to give President-elect Donald Trump more say over how government funding is handled.
A SUSPECTED Chinese spy who was friends with Prince Andrew has been unmasked for the first time.
Читать дальше...
With Christmas Day fast approaching, you may wonder just how to rid your home of nasty pests before hosting any guests over the festive season - but this spice will help
THE government has delayed the second phase of a major pensions review that is aiming to boost the retirement incomes of millions by £11,000.
Читать дальше...
The British government on Monday cleared Czech billionaire Daniel Kretinsky's purchase of the Royal Mail's parent company, the International Distribution Services, for $4.56 billion.
Karisma Kapoor, gracing Indian Idol 15's "100 Years of Raj Kapoor" celebration, shared a humorous anecdote. She revealed how being Raj Kapoor's granddaughter often resulted in free taxi rides abroad. After revealing her lineage, drivers would search online, recognizing her famous grandfather, leading to complimentary fares. The Kapoor family recently held a grand celebration honoring Raj Kapoor's cinematic legacy.
Ferocious winds from storm Chido strike island after ‘incredibly high’ temperatures in Indian Ocean
Driven by the green transition and geopolitical uncertainty, demand for critical minerals is rapidly increasing, underscoring the need for sustainable mining practices that support climate and biodiversity goals. A binding international agreement is needed to ensure accountability across the entire mining value chain.
Vulnerable mother hid her adult daughter's body in house in east London 'as she couldn't accept she'd died'
Journalism pulled off a minor upset in winning Saturday's Grade II Los Alamitos Futurity over some of trainer Bob Baffert's best 2-year-olds, jumping squarely into the Kentucky Derby picture.
Stressed by Work he chose to cut off his fingers
What better time to celebrate our treasured friends than the holidays! This beautifully sculpted ornament features a pair of silvery-white horses moving in sync. Adorned with wreathes and berries, they're joined by an ornate heart and trail a ribbon saying "Best ..
Читать дальше...
This fire pit makes for an excellent Christmas gift, but the deal is only valid until the end of the day.
Ousted Syrian President Bashar Assad says he had no plans to leave the country after the fall of Damascus a week ago but the Russian military evacuated him after their base in western Syria came under attack.
Donald Trump hasn’t yet begun his second term, but his allies are already setting the stage for a third administrative run under the president-elect.
Читать дальше...