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Новости за 16.12.2024

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Spatiotemporal dynamics of grassland aboveground biomass in northern China and the alpine region: Impacts of climate change and human activities

Plos.org 
En

by Xinyun Wang, Ji Zhu, Peipei Pan

Grassland plays a crucial role in the global cycles of matter, energy, water and, climate regulation. Biomass serves as one of the fundamental indicators for evaluating the ecological status of grassland. This study utilized the Carnegie-Ames-Stanford Approach (CASA) model to estimate Net Primary Productivity (NPP) from meteorological data and the Global Inventory Monitoring and Modeling System (GIMMS) Normalized Difference Vegetation Index (NDVI) remote... Читать дальше...

Psycho-physical interactions in Parkinson’s Disease: Protocol for a prospective observational cohort study

Plos.org 
En

by Philip Hodgson, Alastair Jordan, Charikleia Sinani, Divine Charura

Background

Individuals with Parkinson’s Disease (PD) often experience not only physical symptoms but also a higher prevalence of psychological issues, including depression, anxiety, schizophrenia, and psychotic symptoms, compared to the general population. The relationship between these physical and psychological symptoms remains poorly understood, particularly in relation to commonly used measures of physical function and a wider variety of psychological symptoms. Читать дальше...

Study on the mechanical behavior and rupture characteristics of coal after thermal damage

Plos.org 
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by Chuan Li, Yiping Zhang, Haijiao Bu, Hong Lan, Xianwei Heng

High temperature is a critical safety concern that poses challenges to the safe and efficient operation of coal mines. To explore the mechanical behavior and fracture mechanisms of coal exposed to high temperatures, coal samples were subjected to various thermal treatments. After cooling, uniaxial compression tests were performed using an electronic universal testing machine to assess their macroscopic properties. A discrete element numerical model... Читать дальше...



Associations between dietary mycotoxins exposures and risk of hepatocellular carcinoma in a European cohort

Plos.org 
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by Inge Huybrechts, Inarie Jacobs, Carine Biessy, Elom K. Aglago, Mazda Jenab, Liesel Claeys, Jiri Zavadil, Corinne Casagrande, Genevieve Nicolas, Ghislaine Scelo, Andrea Altieri, Beatrice Fervers, Isabelle P. Oswald, Julien Vignard, Bernadette Chimera, Maria Santucci de Magistris, Giovanna Masala, Domenico Palli, Lisa Padroni, Jesús Castilla, Ana Jiménez-Zabala, Pauline Frenoy, Francesca Romana Mancini, Xuan Ren, Emily Sonestedt, Paolo Vineis, Alicia Heath, Mårten Werner, Esther Molina-Montes, Christina C. Читать дальше...

In vitro safety evaluation of dopamine D3R antagonist, R-VK4-116, as a potential medication for the treatment of opioid use disorder

Plos.org 
En

by Rahul M. Nandre, Amy Hauck Newman, Pramod S. Terse

R-VK4-116 is currently being developed as a medication to treat opioid use disorder (OUD). To characterize in vitro safety properties of R-VK4-116, metabolic stability in hepatocytes or liver microsomes, metabolite identification, metabolism/transporter-mediated drug interactions, lysosomal perturbation, mitochondrial toxicity, off-target enzyme effects, cellular and nuclear receptor functional assays, electrophysiological assays, CiPA... Читать дальше...

Barriers and enablers for implementation of clinical practice guidelines in maternity and neonatal settings: A rapid review

Plos.org 
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by Kalpana Raghunathan, Christine East, Kritika Poudel

Background

Maternity and neonatal services are rapidly changing in Australia because of evolving needs of the community and patient population. Clinical practice guidelines focused on early interventions and prevention strategies can decrease risk for preventable negative health outcomes in this population. However, despite the existence of several clinical practice guidelines, their translation into practice remains problematic for healthcare services. Читать дальше...

Right atrial volume index and right atrial volume predict atrial fibrillation recurrence: A meta-analysis

Plos.org 
En

by Jia-Ming Han, Qian Xie, Xiu-Ying Song, Yu-lan Ma

Background

Atrial volume index and atrial volume have recently been identified as predictors of atrial fibrillation (AF) recurrence following electrical cardioversion or radiofrequency ablation. However, most studies have reported the relationship between LAVI/LAV and AF recurrence, whereas there is little information on the relationship between RAVI/RAV and AF recurrence. Therefore, we performed a meta-analysis to assess the relationship... Читать дальше...

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