Новости за 27.12.2024

St-N, a novel alkaline derivative of stevioside, reverses docetaxel resistance by targeting lysosomes in vitro and in vivo

27.12.2024 17:00

Plos.org 

En

by Yanxia Guo, Shikang Wang, Qun Liu, Yan Dong, Yongqing Liu

Drug resistance of cancers remains a major obstacle due to limited therapeutics. Lysosome targeting is an effective method for overcoming drug resistance in cancer cells. St-N (ent-13-hydroxy-15-kaurene-19-acid N-methylpiperazine ethyl ester) is a novel alkaline stevioside derivative with an amine group. In this study, we found that docetaxel (Doc)-resistant prostate cancer (PCa) cells were sensitive to St-N. Mechanistically, the... Читать дальше...

AptaFluorescence: An aptamer-based fluorescent imaging protocol for biomolecule visualization

27.12.2024 17:00

Plos.org 

En

by Crystal Chia Yin Ling, Melissa Jane Fullwood

Immunofluorescence is highly dependent on antibody-antigen interactions for accurate visualization of proteins and other biomolecules within cells. However, obtaining antibodies with high specificity and affinity for their target proteins can be challenging, especially for targets that are complex or naturally present at low levels. Therefore, we developed AptaFluorescence, a protocol that utilizes fluorescently labeled aptamers for in vitro biomolecule visualization. Читать дальше...

Correction: The influence of successor’s implicit power and explicit power on dual innovation———The mediating effect of board dissent

27.12.2024 17:00

Plos.org 

En

by Wang Feifei, Wu Jiong, Marcello Russo, Luyang Gao

Correction: Sulfate activation of wheat straw ash to enhance the properties of high-performance concrete with recycled aggregates and waste tire steel fibers

27.12.2024 17:00

Plos.org 

En

by Fadi Althoey, Osama Zaid, Khaled Mohamed Elhadi

Correction: Capital structure and financial performance of China’s energy industry: What can we infer from COVID-19?

27.12.2024 17:00

Plos.org 

En

by Ahmed Samour, Abdullah AlGhazali, Mihaela Gadoiu, Mariana Banuta

Correction: The Cyprus Institute of Neurology and Genetics, an emerging paradigm of a gender egalitarian organisation

27.12.2024 17:00

Plos.org 

En

by Stavroulla Xenophontos, Margarita Zachariou, Pavlos Polycarpou, Elena Ioannidou, Vera Kazandjian, Maria Lagou, Anna Michaelidou, George M. Spyrou, Marios A. Cariolou, Leonidas Phylactou

Correction: Mapping of UK Biobank clinical codes: Challenges and possible solutions

27.12.2024 17:00

Plos.org 

En

by Oleg Stroganov, Alena Fedarovich, Emily Wong, Yulia Skovpen, Elena Pakhomova, Ivan Grishagin, Dzmitry Fedarovich, Tania Khasanova, David Merberg, Sándor Szalma, Julie Bryant

Correction: Myoglobin regulates fatty acid trafficking and lipid metabolism in mammary epithelial cells

27.12.2024 17:00

Plos.org 

En

by Julia Armbruster, Mostafa A. Aboouf, Max Gassmann, Angela Egert, Hubert Schorle, Veit Hornung, Tobias Schmidt, Jonathan L. Schmid-Burgk, Glen Kristiansen, Anne Bicker, Thomas Hankeln, Hao Zhu, Thomas A. Gorr

Correction: Authentication of Allium ulleungense, A. microdictyon and A. ochotense based on super-barcoding of plastid genome and 45S nrDNA

27.12.2024 17:00

Plos.org 

En

by Minyoung Lee, Hyo Young Lee, Jong-Soo Kang, Hyeji Lee, Ki-Jin Park, Jee Young Park, Tae-Jin Yang

A novel strain of Leishmania braziliensis harbors not a toti- but a bunyavirus

27.12.2024 17:00

Plos.org 

En

by Alexei Yu. Kostygov, Danyil Grybchuk, Senne Heeren, Evgeny S. Gerasimov, Donnamae Klocek, Aditya Reddy, Jovana Sádlová, Lenka Pacáková, Alain Kohl, František Stejskal, Petr Volf, Jean-Claude Dujardin, Vyacheslav Yurchenko

Читать дальше...

The Burr distribution as a model for the delay between key events in an individual’s infection history

27.12.2024 17:00

Plos.org 

En

by Nyall Jamieson, Christiana Charalambous, David M. Schultz, Ian Hall

Читать дальше...

Therapeutic dose prediction of α5-GABA receptor modulation from simulated EEG of depression severity

27.12.2024 17:00

Plos.org 

En

by Alexandre Guet-McCreight, Frank Mazza, Thomas D. Prevot, Etienne Sibille, Etay Hay

Читать дальше...

Scientists Say They Know How to Find Dyson Rings—and Supercharge the Search for Aliens

27.12.2024 17:00

PopularMechanics.com 

En

New methods could uncover hidden megastructures in distant stellar systems.

How this Vancouver developer turned a unicycling obsession into a video game

27.12.2024 17:00

CBC 

En

A video game released earlier this year allows users to ride a unicycle through Vancouver-inspired cityscapes and perform various tricks, all to a soundtrack of pumping punk rock music made entirely by local bands.

Rafael Nadal 'could coach Carlos Alcaraz' like Novak Djokovic and Andy Murray partnership

27.12.2024 17:00

Express.co.uk (tennis) 

En

Now Rafael Nadal has retired from playing, one tennis icon has tipped the Spaniard to follow in Andy Murray's footsteps by teaming up with Carlos Alcaraz.

How Does a Movie Projector Show the Color Black?

27.12.2024 17:00

Wired Magazine 

En

There’s no such thing as black-colored light. So how can we see Darth Vader on a screen?

Israel Conducts Largest Strike on Houthi Targets in Yemen

27.12.2024 17:00

The Trumpet 

En

The Most Memorable Advice of 2024

27.12.2024 17:00

The Atlantic  

En

Musings to carry from one year to the next

AI upscaling killed native graphics gaming. We’re better off for it

27.12.2024 17:00

PC World 

En

Even for me, someone who’s an avid graphics card hardware enthusiast, it took some time to warm up to the idea of AI rdesolution upscaling.

Читать дальше...

Unemployment isn’t recession-ready — but it’s getting better, says acting Labor secretary

27.12.2024 17:00

NEXTgov 

En

Julie Su, the acting Department of Labor secretary, has often been scrutinized for her role in California during the pandemic. She sat down with Nextgov/FCW to talk about unemployment four years later.

9 Best Bamboo Sheets of 2024 for Cooler, Cozier Sleeps

27.12.2024 17:00

GQ.com 

En

Better sleep is just a bamboo sheet set away.

'Light Roast,' 'Arabica' and 'Fairtrade': Here's What All the Fancy Words on Coffee Labels Actually Mean

27.12.2024 17:00

Cnet.com 

En

If you're kind of but not really sure what all the words on coffee labels mean, we devised a helpful guide to common coffee bean lingo.

Want Financial Success in 2025? Make These 10 Money Moves Before the Year Is Up

27.12.2024 17:00

Cnet.com 

En

Don't let 2024 end without taking these steps. You'll be thankful you did.

"A fracture won’t stop me": Actress Deekshha Sonalkar Tham opens up about her injury and passion for acting

27.12.2024 17:00

Timesofindia.indiatimes.com (sports) 

En

Deekshha Sonalkar Tham, currently starring in Kaise Mujhe Tum Mil Gaye, continues working despite sustaining a painful foot injury. She shares her experience of pushing through the pain out of love for her work and a sense of responsibility. With support from co-stars, Deekshha navigates the challenging daily soap schedule.

December 27, 2024 - 1400 UTC

27.12.2024 17:00

Voice of America 

En