Assioma pedals with Look cleats

I've been riding with Look pedals/cleats and recently purchased the Assioma Duo power meters. The Look cleats clip into the Assioma pedals, but do they provide the same axis location under the ball of the foot? I've used them without adjustment on rides up to 65 miles with no problems, but on yesterday's 125 miler, I started to experience pain in my big toes and I wonder if it's due to incorrect cleat placement.

Thanks for any insights,
Nick