Abstract: We calculate the sensitivity of space-based cosmic neutrino detection from transient sources in the context of the Probe Of Extreme Multi-Messenger Astrophysics (POEMMA) mission using Target- of-Opportunity (ToO) observations. POEMMA uses two spacecraft each with a large Schmidt telescope to simultaneously view the optical signals generated by extensive air showers (EASs). POEMMA is designed for both ultrahigh-energy cosmic ray and very-high-energy neutrino measurements. POEMMA has significan...