The changes of the peripheral CD4+ lymphocytes and inflammatory cytokines in Patients with COVID-19

by Hua-Bao Sun, Yi-Ming Zhang, Li-Gui Huang, Qi-Nan Lai, Qun Mo, Xin-Zhou Ye, Tao Wang, Zhong-Zhen Zhu, Xiao-Lin Lv, Yan-Ji Luo, Shi-Ding Gao, Jin-Song Xu, Hao-Hao Zhu, Ting Li, Zhan-Ke Wang

To investigate the clinical value of changes in the subtypes of peripheral blood lymphocytes and levels of inflammatory cytokines in patients with COVID-19, the total numbers of lymphocytes and CD4+ lymphocytes and the ratio of CD4+/CD8+ lymphocytes were calculated and observed in different groups of patients with COVID-19. The results show that the lymphocytopenia in patients with COVID-19 was mainly manifested by decreases in the CD4+ T lymphocyte number and the CD4+/CD8+ ratio. The decreased number of CD4+ T lymphocytes and the elevated levels of TNF-α and IL-6 were correlated with the severity of COVID-19 disease.