Untwisting DNA reveals new force that shapes genomes

Advances in microscopy reveal how the human genome organises itself in three-dimensional space at much higher resolution than previously possible. A new study finds that transcription generates a force that moves across DNA strands like ripples through water. The discovery may have future implications for the understanding of genetic diseases such as Cornelia de Lange syndrome, developmental disorders linked to chromatin folding, and open new avenues of research in genome fragility and cancer development.