Which region is the hardest in the 2022 Men's NCAA Tournament bracket?

The 2022 Men’s NCAA Tournament officially gets underway tonight with two First Four games as 16-seeds Texas A&M-CC and Texas Southern and 12-seeds Indiana and Wyoming fight for a spot in the main bracket.

Each region has its own intriguing matchups and Cinderella potentials, but which one is the hardest? Which 1-seed has the easiest path to the Final Four? Which non-top seeded team has the best opportunity to score an upset?

We take a look at each region — ranking them from hardest to easiest — and which has the best odds to make the Final Four. All odds courtesy of Tipico Sportsbook.