The evolution of the brain and nervous system in animals has been wound back more than 400 million years, thanks to the examination of fossil remains of ancient lungfish providing a missing link in the emergence of land-living, four-legged animals on Earth. Researchers have compared detailed 3D models of cranial endocasts from six Paleozoic lungfish fossils to the brain spaces of the surviving sister group of land vertebrates, to better understand brain evolution of lungfishes.