US Open 2022: When does the US Open start? Will Serena Williams make a run? Why is Novak Djokovic absent?

The 2022 US Open, the final Grand Slam of the year, starts Monday, and it looks like it'll be a special one. Read on for information about the schedule, odds for women and men, and broadcast and streaming info.

When does the US Open start?

The US Open begins Monday, August 29 and ends on Sunday, Sept. 11. The round-by-round schedule is below.

• Round 1: August 29-30, 11:00am ET start

• Round 2: August 31-Sept. 1, 11:00am ET start

• Round 3: Sept. 2-3, 11:00am ET start

• Round 4: Sept. 4-5, 11:00am ET start

• Quarterfinals: Sept. 6-7, 12:00pm ET start

• Women’s singles semifinals: Sept. 8, 7:00pm ET start

• Men’s singles semifinals: Sept. 9, 3:00pm ET start

• Women’s singles final: Sept. 10, 4:00pm ET

• Men’s singles final: Sept. 11, 4:00pm ET

What are the key storylines at the US Open?

• Will Serena Williams make a deep run? Williams, arguably the greatest women's tennis player of all time, is saying goodbye to the sport she changed forever. The US Open will be the final tournament of her stellar career. Since the 40-year-old legend has won it six times, could she go on one last deep run to the finals? It's certainly possible, since she's Serena Williams and we've seen her do incredible things. But judging from her recent public matches, she's just not there form-wise. There's no doubt she'll do her best to wow the friendly audience, but she's ready to move on. This final appearance at the US Open is more about leaving tennis on her own terms than trying to prove she's the player she was at her peak.

• Where is Novak Djokovic? Djokovic is not allowed to enter the United States for the same reason he was deported from Australia ahead of the Australian Open: He's chosen to remain unvaccinated against COVID-19. The US requires all foreign visitors to be fully vaccinated against COVID, and since he's not, he won't be able to play at the US Open. Djokovic waited until Thursday to officially withdraw from the event.

Who are the top 10 seeds?

Here are the top 10 seeds for men's singles:

1. Daniil Medvedev

2. Rafael Nadal

3. Carlos Alcaraz

4. Stefanos Tsitsipas

5. Casper Ruud

6. Felix Auger-Aliassime

7. Cameron Norrie

8. Hubert Hurkacz

9. Andrey Rublev

10. Taylor Fritz

Here are the top 10 seeds for women's singles:

1. Iga Swiatek

2. Anett Kontaveit

3. Maria Sakkari

4. Paula Badosa

5. Ons Jabeur

6. Aryna Sabalenka

7. Jessica Pegula

8. Danielle Collins

9. Garbine Muguruza

10. Emma Raducanu

Who has the best odds of winning the 2022 US Open?

Djokovic, despite not being able to legally enter the United States, was still considered the favorite before he pulled out of the tournament Thursday. With Djokovic officially out, the odds have shifted and Daniil Medvedev is leading the way.

• Daniil Medvedev +225

• Rafael Nadal +400

• Carlos Alcaraz +450

• Nick Kyrgios +700

To no one's surprise, Swiatek leads the odds for women's singles.

• Iga Swiatek +450

• Simona Halep +700

• Emma Raducanu +1400

• Naomi Osaka +1400

• Coco Gauff +1400

How to watch the US Open

ESPN, ESPN2, and ESPN+ are where you can catch all the action for the 2022 US Open. Marquee matches will be broadcast on ESPN and ESPN2, which comes with pretty much every cable package, as well as general coverage of all the matches on a particular day. If you subscribe to ESPN through your cable company, you'll be able to stream live coverage online. 

For coverage of every single match, you need ESPN+, which is ESPN's paywalled streaming service.

Al Bello via Getty Images