Giants RB Saquon Barkley (ankle) ruled out vs. 49ers

(Photo credit: Joe Camporeale-USA TODAY Sports)
New York Giants star running back Saquon Barkley has been ruled out of Thursday's road game against the San Francisco 49ers due to a sprained ankle.

Giants coach Brian Daboll initially told reporters on Tuesday that Barkley would be a game-time decision against the 49ers (2-0). On Wednesday, the team's injury report listed Barkley as out, along with offensive linemen Andrew