Scotland's Kinghorn returns for Six Nations clash with England
Scotland coach Gregor Townsend has also selected Kyle Steyn and former captain Jamie Ritchie in his starting XV following an agonising 20-16 loss to France in the second round.
Kyle Rowe, Harry Paterson and Matt Fagerson -- who all started against Les Bleus - have been dropped from the matchday 23 entirely, with the bench unchanged.
Full-back Kinghorn missed the opening two matches of the Six Nations through injury, while wing Steyn was a late dropout against France after his wife went into labour.
Blindside flanker Ritchie returns to the back row after starting in Scotland's dramatic 27-26 first-round victory over Wales in Cardiff.
Scotland are bidding for a fourth successive win over oldest rivals England, who are due to name their team later Thursday.
Scotland team to play England in the Six Nations at Murrayfield on Saturday (kick-off 1645 GMT):
Team (15-1)
Blair Kinghorn; Kyle Steyn, Huw Jones, Sione Tuipulotu, Duhan van der Merwe; Finn Russell (co-capt), Ben White; Jack Dempsey, Rory Darge (co-capt), Jamie Ritchie; Scott Cummings, Grant Gilchrist; Zander Fagerson, George Turner, Pierre Schoeman
Replacements: Ewan Ashman, Alec Hepburn, Elliot Millar-Mills, Sam Skinner, Andy Christie, George Horne, Ben Healy, Cameron Redpath
Coach: Gregor Townsend (SCO)