Derivation and simulation of a computational model of active cell populations: How overlap avoidance, deformability, cell-cell junctions and cytoskeletal forces affect alignment
by Vivienne Leech, Fiona N. Kenny, Stefania Marcotti, Tanya J. Shaw, Brian M. Stramer, Angelika Manhart
Collective alignment of cell populations is a commonly observed phenomena in biology. An important example are aligning fibroblasts in healthy or scar tissue. In this work we derive and simulate a mechanistic agent-based model of the collective behaviour of actively moving and interacting cells, with a focus on understanding collective alignment. The derivation strategy is based on energy minimisation. The model ingredients are motivated by data on the behaviour of different populations of aligning fibroblasts and include: Self-propulsion, overlap avoidance, deformability, cell-cell junctions and cytoskeletal forces. We find that there is an optimal ratio of self-propulsion speed and overlap avoidance that maximises collective alignment. Further we find that deformability aids alignment, and that cell-cell junctions by themselves hinder alignment. However, if cytoskeletal forces are transmitted via cell-cell junctions we observe strong collective alignment over large spatial scales.
Metaphor: ReFantazio's ReViews are in, and the Persona follow-up looks like 2024's unanimous RPG hit
Epic Boss Tim Sweeney says Unreal Engine 6 will be a 'metaverse' joining Fortnite and other Unreal games, including an upcoming 'persistent universe' in development with Disney
A Quake 2 Remaster dev has rebuilt the game's unique PlayStation port from scratch and released it as a free add-on
The Big Catch: Tacklebox is the hardest 3D platformer I've ever played, 8+ hours long, and a free to play 'prologue' to a bigger, better game on the way
Певица Натали Орли спела для самых ярких бизнес-леди России
«Человек поет такие песни! Вы бы никогда не подумали, что он такой козёл!» Певица Бьянка рассказала о домогательствах известного певца в студии «Шоу Воли» на ТНТ
Содружественные страны // Главы МИДов государств СНГ выступили на разогреве перед лидерами
Мари Краймбрери, Клава Кока, bearwolf и не только! Like FM устраивает звездный девичник