Pharmaceutical products, drugs and personal care products in European waters: A protocol for systematic review and meta-analysis

by Manuel Serrano Valera, Isabel Martínez-Alcalá, Grasiela Piuvezam, Francisco Mateo-Ramírez, Isac Davidson Santiago Fernandes Pimenta, Nuria Vela

This study aims to describe a protocol for a systematic review and meta-analysis that assesses the detection and concentration of pharmaceutical products, drugs, and personal care products in European waters. This study protocol was developed following the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA-P) statement and the Cochrane Handbook of Systematic Reviews of Interventions. We will include studies conducted on European waters of various origins (watersheds, aquifers, rivers, seas, springs, wastewaters, and drinking water). A comprehensive search strategy will be implemented in the following databases: PubMed (Medline), EMBASE, Scopus, and Web of Science. Two independent reviewers will conduct all study selection procedures, data extraction, and methodological evaluation. Any disagreements will be referred to a third reviewer. If the studies are sufficiently homogeneous, we will conduct a meta-analysis to summarize the data. We will use the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) to assess the certainty of the evidence. The systematic review and meta-analysis will provide valuable information about the presence and concentration of these types of contaminants in water, aiding in the development of public policies regarding prevention and decontamination measures to enhancing water quality in Europe.