by Alison Robert, David Crottès, Jérôme Bourgeais, Naig Gueguen, Arnaud Chevrollier, Jean-François Dumas, Stéphane Servais, Isabelle Domingo, Stéphanie Chadet, Julien Sobilo, Olivier Hérault, Thierry Lecomte, Christophe Vandier, William Raoul, Maxime Guéguinou
The mitochondrial Ca2+ uniporter (MCU) plays crucial role in intramitochondrial Ca2+ uptake, allowing Ca2+-dependent activation of oxidative metabolism. In recent decades, the role of MCU pore-forming proteins has been highlighted in cancer. However, the contribution of MCU-associated regulatory proteins mitochondrial calcium uptake 1 and 2 (MICU1 and MICU2) to pathophysiological conditions has been poorly investigated. Here, we describe the role of MICU2 in cell proliferation and invasion using in vitro and in vivo models of human colorectal cancer (CRC). Transcriptomic analysis demonstrated an increase in MICU2 expression and the MICU2/MICU1 ratio in advanced CRC and CRC-derived metastases. We report that expression of MICU2 is necessary for mitochondrial Ca2+ uptake and quality of the mitochondrial network. Our data reveal the interplay between MICU2 and MICU1 in the metabolic flexibility between anaerobic glycolysis and OXPHOS. Overall, our study sheds light on the potential role of the MICUs in diseases associated with metabolic reprogramming.
Алмазы в Whiteout Survival: где собирать, как приумножать и на что тратить
This underwater city builder had me more emotionally invested in my corals than SimCity does in my human citizens, and you can try it at the next Steam Next Fest
Metal Force 3.51.0
Игра Cultivation Chat Group заняла топ-7 в китайском App Store
Заместитель прокурора Архангельской области и Ненецкого автономного округа Павел Матанцев провел личный прием работников ГУП НАО «Нарьян-Марская электростанция»
Жара накроет регионы России
Один человек погиб, четверо пострадали в ДТП в Архангельской области
Арктика с женским лицом: Архангельск готовится к масштабному форуму лидеров и идей
