A novel hydrogen sensor offers a promising solution for real-time hydrogen leak detection, addressing safety concerns in industrial applications. This sensor, made with nano-patterned cupric-oxide (CuO) nanowires (NWs) with voids, can detect hydrogen at extremely low concentrations with high response, recovery speed, and precision, significantly improving previous CuO-based sensors. It has the potential to enable safer and more reliable use of hydrogen in clean energy applications.