Guglielmo Vicario, Micky van de Ven, Cristian Romero, Ben Davies, Wilson Odobert and Destiny Udogie all remain sidelined.
James Maddison and Pape Matar Sarr are both suspended, however, Rodrigo Bentancur is once again available after serving his one-match ban in the 2-1 defeat to Newcastle United last weekend.
A sickness bug caused Postecoglou some selection issues against the Magpies. Fraser Forster was bedridden for the match, while Radu Dragusin could only manage to play the first half.
Liverpool come into the fixture having been held to a 2-2 draw against a spirited Manchester United side at a snowy Anfield.
Tottenham injury update ahead of Liverpool cup fixture
The Spurs boss has revealed that a number of his players are feeling better after the virus outbreak and Mikey Moore could be set for a place on the bench.
Postecoglou told Football.London: “Net wise I still think we’re down. Bentancur back but lose Maddison and Sarr. Mikey potentially could be back on the bench.
“Everyone from the weekend certainly feels better. Radu is better and Archie. Deki was a bit under the weather but he should be fine.”
Tottenham vs Liverpool will take place on Wednesday evening at the Tottenham Hotspur Stadium with kick-off at 8pm UK time, with the match being televised live in Great Britain on Sky Sports Main Event.
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