Gluten, lactose in drugs? Study raises questions about risk

WASHINGTON (AP) — A man with celiac disease felt sicker after starting a new drug, but it wasn't a typical side effect. It turns out the pills were mixed with gluten the patient knew to avoid in food — but was surprised to find hiding in medicine.

A new report says pills often contain so-called "inactive" ingredients capable of causing allergic or gastrointestinal reactions in small numbers of people sensitive to specific compounds.

And it's hard for those patients, or even their doctors, to tell if a pill contains an extra ingredient they should avoid, researchers from the Massachusetts Institute of Technology and Boston's Brigham and Women's Hospital said Wednesday. When the doctor sends a prescription, the pharmacist issues whatever the person's insurance covers — without discussion of inactive ingredients that are buried in the drug's labeling.

"There's a tremendous underappreciation of the potential impact that inactive ingredients may have," said Dr. Giovanni Traverso, a Brigham gastroenterologist who spurred the research after his celiac patient's trouble.

Drugs contain an "active ingredient," what you hope will help your health. Patients may not realize that inactive ingredients make up the rest of the pill, substances that aren't supposed to directly affect your health. They're used to make it easier to absorb the drug, or to improve the taste or extend the shelf life.

Most people don't need to worry about inactive ingredients but the Boston researchers pointed to rare published reports of reactions in patients with allergies or intolerances to certain compounds — and called for more information about who might be at risk.

The study analyzed data on inactive ingredients from a database of more than 42,000 prescription and over-the-counter medicines. An average pill contains eight inactive...