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Август
2019

Новости за 02.08.2019

Diagnostic performance of a single and duplicate Kato-Katz, Mini-FLOTAC, FECPAKG2 and qPCR for the detection and quantification of soil-transmitted helminths in three endemic countries

Plos.org 

by Piet Cools, Johnny Vlaminck, Marco Albonico, Shaali Ame, Mio Ayana, Barrios Perez José Antonio, Giuseppe Cringoli, Daniel Dana, Jennifer Keiser, Maria P. Maurelli, Catalina Maya, Leonardo F. Matoso, Antonio Montresor, Zeleke Mekonnen, Greg Mirams, Rodrigo Corrêa-Oliveira, Simone A. Pinto, Laura Rinaldi, Somphou Sayasone, Eurion Thomas, Jaco J. Verweij, Jozef Vercruysse, Bruno Levecke

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Therapeutic efficacy of albendazole against soil-transmitted helminthiasis in children measured by five diagnostic methods

Plos.org 

by Johnny Vlaminck, Piet Cools, Marco Albonico, Shaali Ame, Mio Ayana, Giuseppe Cringoli, Daniel Dana, Jennifer Keiser, Maria P. Maurelli, Leonardo F. Matoso, Antonio Montresor, Zeleke Mekonnen, Greg Mirams, Rodrigo Corrêa-Oliveira, Simone A. Pinto, Laura Rinaldi, Somphou Sayasone, Eurion Thomas, Jozef Vercruysse, Jaco J. Verweij, Bruno Levecke

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Induction of systemic, mucosal and memory antibody responses targeting Vibrio cholerae O1 O-specific polysaccharide (OSP) in adults following oral vaccination with an oral killed whole cell cholera vaccine in Bangladesh

Plos.org 

by Aklima Akter, Pinki Dash, Amena Aktar, Sultana Rownok Jahan, Sadia Afrin, Salima Raiyan Basher, Al Hakim, Asura Khanam Lisa, Fahima Chowdhury, Ashraful I. Khan, Peng Xu, Richelle C. Charles, Meagan Kelly, Pavol Kováč, Jason B. Harris, Taufiqur Rahman Bhuiyan, Stephen B. Calderwood, Edward T. Ryan, Firdausi Qadri

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Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome

Plos.org 

by Amanda Vlahos, Toby Mansell, Richard Saffery, Boris Novakovic

The placenta is the interface between maternal and fetal circulations, integrating maternal and fetal signals to selectively regulate nutrient, gas, and waste exchange, as well as secrete hormones. In turn, the placenta helps create the in utero environment and control fetal growth and development. The unique epigenetic profile of the human placenta likely reflects its early developmental separation from the fetus proper and... Читать дальше...

Efficiency of protein synthesis inhibition depends on tRNA and codon compositions

Plos.org 

by Sophia Rudorf

Regulation and maintenance of protein synthesis are vital to all organisms and are thus key targets of attack and defense at the cellular level. Here, we mathematically analyze protein synthesis for its sensitivity to the inhibition of elongation factor EF-Tu and/or ribosomes in dependence of the system’s tRNA and codon compositions. We find that protein synthesis reacts ultrasensitively to a decrease in the elongation factor’s concentration for systems with an imbalance between codon usages and tRNA concentrations. Читать дальше...

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