by Natalia E. Jiménez, Ziomara P. Gerdtzen, Álvaro Olivera-Nappa, J. Cristian Salgado, Carlos Conca
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by Frédéric Fercoq, Estelle Remion, Stefan J. Frohberger, Nathaly Vallarino-Lhermitte, Achim Hoerauf, John Le Quesne, Frédéric Landmann, Marc P. Hübner, Leo M. Carlin, Coralie Martin
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by Patrick Giraudoux, YuMin Zhao, Eve Afonso, HongBin Yan, Jenny Knapp, Michael T. Rogan, DaZhong Shi, WanZhong Jia, Philip S. Craig
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by Pau Bosch-Nicolau, Maria Ubals, Fernando Salvador, Adrián Sánchez-Montalvá, Gloria Aparicio, Alba Erra, Pablo Martinez de Salazar, Elena Sulleiro, Israel Molina
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by Shahreen Raihana, Michael J. Dibley, Mohammad Masudur Rahman, Tazeen Tahsina, Md. Abu Bakkar Siddique, Qazi Sadequr Rahman, Sajia Islam, Ashraful Alam, Patrick J. Kelly, Shams El Arifeen, Tanvir M Huda
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by Izukanji Sikazwe, Ingrid Eshun-Wilson, Kombatende Sikombe, Nancy Czaicki, Paul Somwe, Aaloke Mody, Sandra Simbeza, David V. Glidden, Elizabeth Chizema, Lloyd B. Mulenga, Nancy Padian, Chris J. Duncombe, Carolyn Bolton-Moore, Laura K. Beres, Charles B. Holmes, Elvin Geng
by Shaoke Lou, Kellie A. Cotter, Tianxiao Li, Jin Liang, Hussein Mohsen, Jason Liu, Jing Zhang, Sandra Cohen, Jinrui Xu, Haiyuan Yu, Mark A. Rubin, Mark Gerstein
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by Cavin Wong, Fei Chen, Najmeh Alirezaie, Yifan Wang, Adeline Cuggia, Ayelet Borgida, Spring Holter, Tatiana Lenko, Celine Domecq, Alzheimer’s Disease Neuroimaging Initiative , Gloria M. Petersen, Sapna Syngal, Randall Brand, Anil K. Rustgi, Michele L. Cote, Elena Stoffel, Sara H. Olson, Nicholas J. Roberts, Mohammad R. Akbari, Jacek Majewski, Alison P. Klein, Celia M. T. Greenwood, Steven Gallinger, George Zogopoulos
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by Alexander Kozik, Beth A. Rowan, Dean Lavelle, Lidija Berke, M. Eric Schranz, Richard W. Michelmore, Alan C. Christensen
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by Ryan S. Phillips, Jonathan E. Rubin
The mechanism(s) of action of most commonly used pharmacological blockers of voltage-gated ion channels are well understood; however, this knowledge is rarely considered when interpreting experimental data. Effects of blockade are often assumed to be equivalent, regardless of the mechanism of the blocker involved. Using computer simulations, we demonstrate that this assumption may not always be correct. We simulate the blockade of a persistent sodium current (INaP)... Читать дальше...
by Ming-Wen Hu, Dong Won Kim, Sheng Liu, Donald J. Zack, Seth Blackshaw, Jiang Qian
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by Franca Schmid, Matthew J. P. Barrett, Dominik Obrist, Bruno Weber, Patrick Jenny
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by Joel A. Paulson, Marc Martin-Casas, Ali Mesbah
We present a novel surrogate modeling method that can be used to accelerate the solution of uncertainty quantification (UQ) problems arising in nonlinear and non-smooth models of biological systems. In particular, we focus on dynamic flux balance analysis (DFBA) models that couple intracellular fluxes, found from the solution of a constrained metabolic network model of the cellular metabolism, to the time-varying nature of the extracellular substrate and product concentrations. Читать дальше...
by Vladimir A. Fedorov, Philipp S. Orekhov, Ekaterina G. Kholina, Artem A. Zhmurov, Fazoil I. Ataullakhanov, Ilya B. Kovalenko, Nikita B. Gudimchuk
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by Laxmi Parida, Claudia Haferlach, Kahn Rhrissorrakrai, Filippo Utro, Chaya Levovitz, Wolfgang Kern, Niroshan Nadarajah, Sven Twardziok, Stephan Hutter, Manja Meggendorfer, Wencke Walter, Constance Baer, Torsten Haferlach
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by Hilje M. Doekes, Rob J. de Boer, Rutger Hermsen
The production of anticompetitor toxins is widespread among bacteria. Because production of such toxins is costly, it is typically regulated. In particular, many toxins are produced only when the local cell density is high. It is unclear which selection pressures shaped the evolution of density-dependent regulation of toxin production. Here, we study the evolution of toxin production, resistance and the response to a cell-density cue in a... Читать дальше...
by Guang Gao, Chengjia Zhu, Emma Liu, Ivan R. Nabi
The endoplasmic reticulum (ER) is an expansive, membrane-enclosed organelle composed of smooth peripheral tubules and rough, ribosome-studded central ER sheets whose morphology is determined, in part, by the ER-shaping proteins, reticulon (RTN) and cytoskeleton-linking membrane protein 63 (CLIMP-63), respectively. Here, stimulated emission depletion (STED) super-resolution microscopy shows that reticulon4a (RTN4a) and CLIMP-63 also regulate... Читать дальше...
by Flor I. Arias-Sánchez, Björn Vessman, Sara Mitri
Natural microbial communities perform many functions that are crucial for human well-being. Yet we have very little control over them, and we do not know how to optimize their functioning. One idea is to breed microbial communities as we breed dogs: by comparing a set of microbiomes and allowing the best-performing ones to generate new communities, and so on. Although this idea seems simple, designing such a selection experiment brings with it many decisions with surprising outcomes. Читать дальше...
by Chris D. Jiggins
Evolutionary biologists are increasingly using population genetic variation across genomes to address questions around the origin and ongoing evolution of species. Patterns of differentiation between closely related species are highly variable across the genome, and a wide variety of processes contribute to that variation. There is an emerging pattern of parallelism, whereby different species pairs in groups of related species show similar differentiation patterns across their genomes... Читать дальше...
by Yandong Zhou, Robert M. Nwokonko, James H. Baraniak Jr., Mohamed Trebak, Kenneth P. K. Lee, Donald L. Gill
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by Haitao Wang, Jiahui Chen, Xiaotong Xu, Wen-Jian Sun, Xi Chen, Fei Zhao, Min-Hua Luo, Chunhua Liu, Yiping Guo, Wen Xie, Hui Zhong, Tongjian Bai, Yanghua Tian, Yu Mao, Chonghuan Ye, Wenjuan Tao, Jie Li, Zahra Farzinpour, Juan Li, Jiang-Ning Zhou, Kai Wang, Jufang He, Lin Chen, Zhi Zhang
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Nine FARC dissidents were killed in a bombing raid in southern Colombia, the first since former leaders of the group announced a new offensive this week.
Esther Lin, MMA Fighting
If all goes well for him against Dustin Poirier at UFC 242 next weekend, Khabib Nurmagomedov would move to 28-0 in his career with a second straight title defense in the lightweight division.
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