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Новости за 18.09.2019

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Prevalence of hypochondriac symptoms among health science students in China: A systematic review and meta-analysis

Plos.org 
En

by Jingjing Meng, Chang Gao, Chulei Tang, Honghong Wang, Zirong Tao

Background

Hypochondriac symptoms are commonly reported in health science students. With their incomplete medical knowledge, they may compare their own bodily symptoms with disease symptoms during the process of learning, which can lead to mental distress and the need for repeated medical reassurance.

Objective

To estimate the prevalence of hypochondriac symptoms in Chinese health science students.

Methods

A... Читать дальше...

Direct estimation of the parameters of a delayed, intermittent activation feedback model of postural sway during quiet standing

Plos.org 
En

by Kevin L. McKee, Michael C. Neale

Human postural sway during quiet standing has been characterized as a proportional-integral-derivative controller with intermittent activation. In the model, patterns of sway result from both instantaneous, passive, mechanical resistance and delayed, intermittent resistance signaled by the central nervous system. A Kalman-Filter framework was designed to directly estimate from experimental data the parameters of the model’s stochastic delay differential... Читать дальше...

A mathematical model for designing networks of C-Reactive Protein point of care testing

Plos.org 
En

by Carlos Lamas-Fernandez, Gail Hayward, Michael Moore, Thomas Monks

One approach to improving antibiotic stewardship in primary care may be to support all General Practitioners (GPs) to have access to point of care C-Reactive Protein tests to guide their prescribing decisions in patients presenting with symptoms of lower respiratory tract infection. However, to date there has been no work to understand how clinical commissioning groups might approach the practicalities of system-wide implementation. Читать дальше...



Exocyst-mediated apical Wg secretion activates signaling in the Drosophila wing epithelium

Plos.org 
En

by Varun Chaudhary, Michael Boutros

Wnt proteins are secreted signaling factors that regulate cell fate specification and patterning decisions throughout the animal kingdom. In the Drosophila wing epithelium, Wingless (Wg, the homolog of Wnt1) is secreted from a narrow strip of cells at the dorsal-ventral boundary. However, the route of Wg secretion in polarized epithelial cells remains poorly understood and key proteins involved in this process are still unknown. Here, we performed an in... Читать дальше...

In eubacteria, unlike eukaryotes, there is no evidence for selection favouring fail-safe 3’ additional stop codons

Plos.org 
En

by Alexander T. Ho, Laurence D. Hurst

Errors throughout gene expression are likely deleterious, hence genomes are under selection to ameliorate their consequences. Additional stop codons (ASCs) are in-frame nonsense ‘codons’ downstream of the primary stop which may be read by translational machinery should the primary stop have been accidentally read through. Prior evidence in several eukaryotes suggests that ASCs are selected to prevent potentially-deleterious consequences of read-through. Читать дальше...

New insight into bacterial social communication in natural host: Evidence for interplay of heterogeneous and unison quorum response

Plos.org 
En

by Biswajit Samal, Subhadeep Chatterjee

Many microbes exhibit quorum sensing (QS) to cooperate, share and perform a social task in unison. Recent studies have shown the emergence of reversible phenotypic heterogeneity in the QS-responding pathogenic microbial population under laboratory conditions as a possible bet-hedging survival strategy. However, very little is known about the dynamics of QS-response and the nature of phenotypic heterogeneity in an actual host-pathogen interaction environment. Читать дальше...

Predicting gene regulatory interactions based on spatial gene expression data and deep learning

Plos.org 
En

by Yang Yang, Qingwei Fang, Hong-Bin Shen

Reverse engineering of gene regulatory networks (GRNs) is a central task in systems biology. Most of the existing methods for GRN inference rely on gene co-expression analysis or TF-target binding information, where the determination of co-expression is often unreliable merely based on gene expression levels, and the TF-target binding data from high-throughput experiments may be noisy, leading to a high ratio of false links and missed links, especially for large-scale networks. Читать дальше...

Новости России

Complex genetic and epigenetic regulation deviates gene expression from a unifying global transcriptional program

Plos.org 
En

by Mónica Chagoyen, Juan F. Poyatos

Environmental or genetic perturbations lead to gene expression changes. While most analyses of these changes emphasize the presence of qualitative differences on just a few genes, we now know that changes are widespread. This large-scale variation has been linked to the exclusive influence of a global transcriptional program determined by the new physiological state of the cell. However, given the sophistication of eukaryotic regulation, we expect to have... Читать дальше...

Inside the Blockbuster $600 Million ‘Big Bang Theory’ Streaming Deal With HBO Max - Variety

Top Stories (us) - Google News (com) 
En

  1. Inside the Blockbuster $600 Million ‘Big Bang Theory’ Streaming Deal With HBO Max  Variety
  2. HBO to stream 'The Big Bang Theory' as WarnerMedia prepares to take on Netflix  NBCNews.com
  3. Big Bang Theory shock: Time had no beginning and eventually reverses towards Big Bounce  Express.co.uk
  4. Streaming Services Splurge on Old TV Shows to Fend Off Rivals  The Wall Street Journal
  5. Big Bang Theory lands on HBO Max in deal reportedly worth more than $1 billion  The Verge
  6. View... Читать дальше...

Pose, but Make It Presidential: Actress-Activist Angelica Ross to Host a Democratic Candidate Forum on LGBTQ+ Issues

TheRoot.com 
En

We fell in love with Angelica Ross as the always-ready-with-a-clapback “Candy” on FX’s Pose, but it’ll be the 2020 Democratic presidential candidates who will soon get a taste of the actress and activist’s charm and wit. This Friday, Sept. 20, Ross will host a national presidential candidate forum on LGBTQ+ issues at…

Читать дальше...

Check Out These 3 Insane Cold War Tanks That Were Never Mass Produced

The National Interest 
En

Charlie Gao

Security, Americas

Pretty weird.

Key point: During the Cold War a large number of strange ideas were put forward as each superpower tried to out-do the other.

The United States fielded a pretty standard lineup of tanks during the Cold War. First came the Patton line, which evolved in a pretty straightforward fashion from the M47 to the M60 with a few deviations such as the M60A2 Starship.

Then came the Abrams, which serves on to this day. But American... Читать дальше...


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