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2020

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Новости за 11.04.2020

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A powerful and versatile colocalization test

11.04.2020 00:00

Plos.org

by Yangqing Deng, Wei Pan

Transcriptome-wide association studies (TWAS and PrediXcan) have been increasingly applied to detect associations between genetically predicted gene expressions and GWAS traits, which may suggest, however do not completely determine, causal genes for GWAS traits, due to the likely violation of their imposed strong assumptions for causal inference. Testing colocalization moves it closer to establishing causal relationships: if a GWAS trait and a gene’s expression share the same associated SNP... Читать дальше...

Deep reinforcement learning for the control of microbial co-cultures in bioreactors

11.04.2020 00:00

Plos.org

by Neythen J. Treloar, Alex J. H. Fedorec, Brian Ingalls, Chris P. Barnes

Climbing Escher’s stairs: A way to approximate stability landscapes in multidimensional systems

11.04.2020 00:00

Plos.org

by Pablo Rodríguez-Sínchez, Egbert H. Van Nes, Marten Scheffer

Stability landscapes are useful for understanding the properties of dynamical systems. These landscapes can be calculated from the system’s dynamical equations using the physical concept of scalar potential. Unfortunately, it is well known that for most systems with two or more state variables such potentials do not exist. Here we use an analogy with art to provide an accessible explanation of why this happens and briefly review some of the possible alternatives. Читать дальше...

eXplainable Artificial Intelligence (XAI) for the identification of biologically relevant gene expression patterns in longitudinal human studies, insights from obesity research

11.04.2020 00:00

Plos.org

by Augusto Anguita-Ruiz, Alberto Segura-Delgado, Rafael Alcalá, Concepción M. Aguilera, Jesús Alcalá-Fdez

Resist or perish: Fate of a microbial population subjected to a periodic presence of antimicrobial

11.04.2020 00:00

Plos.org

by Loïc Marrec, Anne-Florence Bitbol

The evolution of antimicrobial resistance can be strongly affected by variations of antimicrobial concentration. Here, we study the impact of periodic alternations of absence and presence of antimicrobial on resistance evolution in a microbial population, using a stochastic model that includes variations of both population composition and size, and fully incorporates stochastic population extinctions. We show that fast alternations of presence and absence... Читать дальше...

ORANGE: A CRISPR/Cas9-based genome editing toolbox for epitope tagging of endogenous proteins in neurons

11.04.2020 00:00

Plos.org

by Jelmer Willems, Arthur P. H. de Jong, Nicky Scheefhals, Eline Mertens, Lisa A. E. Catsburg, Rogier B. Poorthuis, Fred de Winter, Joost Verhaagen, Frank J. Meye, Harold D. MacGillavry

Precise genomic mapping of 5-hydroxymethylcytosine via covalent tether-directed sequencing

11.04.2020 00:00

Plos.org

by Povilas Gibas, Milda Narmontė, Zdislav Staševskij, Juozas Gordevičius, Saulius Klimašauskas, Edita Kriukienė

Rab5c-mediated endocytic trafficking regulates hematopoietic stem and progenitor cell development via Notch and AKT signaling

11.04.2020 00:00

Plos.org

by Jian Heng, Peng Lv, Yifan Zhang, Xinjie Cheng, Lu Wang, Dongyuan Ma, Feng Liu

Celebrities and influencers using social media platforms to keep people at home

11.04.2020 00:00

The Japan Times

A handful of well-known personalities have been out in front of the pandemic on social media.

Good God, Black Widow's Alternate Avengers: Endgame Death Is Infinitely Better Than What We Got

11.04.2020 00:00

Gizmodo.com

Avengers: Endgame did a lot over the course of its bonkers, audacious runtime. For better or worse, it kind of had to. But trying to do so much, tying together 10 years of moviemaking into a single, only occasionally coherent narrative, inevitably meant that some plotlines just would not wrap up satisfyingly in the…

Ya diyetini öde, ya öl!

11.04.2020 00:00

Yenicag

Ya diyetini öde, ya öl!

Devlet, milletten bağış veya borç alabilir mi?

11.04.2020 00:00

Yenicag

Devlet, milletten bağış veya borç alabilir mi?

Öteleme tuzağı

11.04.2020 00:00

Yenicag

Öteleme tuzağı

Aşevi bağışı bloke vatandaşa; geber

11.04.2020 00:00

Yenicag

Aşevi bağışı bloke vatandaşa; geber

Gizem, vahşet, sonuç!!!

11.04.2020 00:00

Yenicag

Gizem, vahşet, sonuç!!!

Cıvıl cıvıl ekranlar ve kahramanları

11.04.2020 00:00

Yenicag

Cıvıl cıvıl ekranlar ve kahramanları

'Turan' birbirine yeter

11.04.2020 00:00

Yenicag

'Turan' birbirine yeter

İnsan hücresine sadece virüs değil, radyasyon da giriyor!

11.04.2020 00:00

Yenicag

İnsan hücresine sadece virüs değil, radyasyon da giriyor!

Suçun anlamı var mı?

11.04.2020 00:00

Yenicag

Suçun anlamı var mı?

Data on coronavirus deaths by country show more men are dying than women. Male habits and health problems may be partly to blame.

11.04.2020 00:00

BusinessInsider.com.au

Men are more likely than women to die of the coronavirus,data from nearly 20 countries suggests. The pattern is particularly pronounced in Italy, where men represent nearly 70% of the country's deceased patients. More »