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Новости за 27.05.2020

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Modeling the effects of motivation on choice and learning in the basal ganglia

Plos.org 
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by Maaike M. H. van Swieten, Rafal Bogacz

Decision making relies on adequately evaluating the consequences of actions on the basis of past experience and the current physiological state. A key role in this process is played by the basal ganglia, where neural activity and plasticity are modulated by dopaminergic input from the midbrain. Internal physiological factors, such as hunger, scale signals encoded by dopaminergic neurons and thus they alter the motivation for taking actions and learning. Читать дальше...

A unifying model for the propagation of prion proteins in yeast brings insight into the [PSI+] prion

Plos.org 
En

by Paul Lemarre, Laurent Pujo-Menjouet, Suzanne S. Sindi

The use of yeast systems to study the propagation of prions and amyloids has emerged as a crucial aspect of the global endeavor to understand those mechanisms. Yeast prion systems are intrinsically multi-scale: the molecular chemical processes are indeed coupled to the cellular processes of cell growth and division to influence phenotypical traits, observable at the scale of colonies. We introduce a novel modeling framework to tackle... Читать дальше...

Balance between asymmetry and abundance in multi-domain DNA-binding proteins may regulate the kinetics of their binding to DNA

Plos.org 
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by Arumay Pal, Yaakov Levy

DNA sequences are often recognized by multi-domain proteins that may have higher affinity and specificity than single-domain proteins. However, the higher affinity to DNA might be coupled with slower recognition kinetics. In this study, we address this balance between stability and kinetics for multi-domain Cys2His2- (C2H2-) type zinc-finger (ZF) proteins. These proteins are the most prevalent DNA-binding domain in eukaryotes and C2H2 type zinc-finger proteins (C2H2-ZFPs)... Читать дальше...

Predicting host taxonomic information from viral genomes: A comparison of feature representations

Plos.org 
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by Francesca Young, Simon Rogers, David L. Robertson

The rise in metagenomics has led to an exponential growth in virus discovery. However, the majority of these new virus sequences have no assigned host. Current machine learning approaches to predicting virus host interactions have a tendency to focus on nucleotide features, ignoring other representations of genomic information. Here we investigate the predictive potential of features generated from four different ‘levels’ of viral genome representation... Читать дальше...

Новости России
Москва

«Гимн Авторадио» – теперь везде, где есть музыка


Predictive whisker kinematics reveal context-dependent sensorimotor strategies

Plos.org 
En

by Avner Wallach, David Deutsch, Tess Baker Oram, Ehud Ahissar

Animals actively move their sensory organs in order to acquire sensory information. Some rodents, such as mice and rats, employ cyclic scanning motions of their facial whiskers to explore their proximal surrounding, a behavior known as whisking. Here, we investigated the contingency of whisking kinematics on the animal’s behavioral context that arises from both internal processes (attention and expectations) and external constraints... Читать дальше...


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