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Новости за 11.08.2020

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Using oxygen 18 isotope to problematize the presence of resettled laborers in the far provinces of the Inca empire

Plos.org 
En

by Francisco Garrido, Catalina Morales

Resettlement, as a major imperial policy in the Inca empire, appears to have been a widespread mechanism for labor mobilization and the dismantling of rebellions. While multiple ethnohistorical references exist regarding resettlement in the central Andes, the extent of this policy in the imperial provinces is still unknown, especially in cases of economic intensification that might have required more labor force. The δ18O isotope is a good proxy for... Читать дальше...

Efficacy of histamine H1 receptor antagonists azelastine and fexofenadine against cutaneous Leishmania major infection

Plos.org 
En

by Alex G. Peniche, E. Yaneth Osorio, Peter C. Melby, Bruno L. Travi

Current drug therapies for cutaneous leishmaniasis are often difficult to administer and treatment failure is an increasingly common occurrence. The efficacy of antileishmanial therapy relies on a combination of anti-parasite activity of drugs and the patient’s immune response. Previous studies have reported in vitro antimicrobial activity of histamine 1-receptor antagonists (H1RAs) against different pathogens. We used an... Читать дальше...

The global progress of soil-transmitted helminthiases control in 2020 and World Health Organization targets for 2030

Plos.org 
En

by Antonio Montresor, Denise Mupfasoni, Alexei Mikhailov, Pauline Mwinzi, Ana Lucianez, Mohamed Jamsheed, Elkan Gasimov, Supriya Warusavithana, Aya Yajima, Zeno Bisoffi, Dora Buonfrate, Peter Steinmann, Jürg Utzinger, Bruno Levecke, Johnny Vlaminck, Piet Cools, Jozef Vercruysse, Giuseppe Cringoli, Laura Rinaldi, Brittany Blouin, Theresa W. Gyorkos

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COVID-19 and acute juvenile paracoccidioidomycosis coinfection

Plos.org 
En

by Priscila Marques de Macedo, Dayvison Francis Saraiva Freitas, Andrea Gina Varon, Cristiane da Cruz Lamas, Livia Cristina Fonseca Ferreira, Andrea d’Avila Freitas, Marcel Treptow Ferreira, Estevão Portela Nunes, Marilda Mendonça Siqueira, Valdiléa G. Veloso, Antonio Carlos Francesconi do Valle

Immediate activation of chemosensory neuron gene expression by bacterial metabolites is selectively induced by distinct cyclic GMP-dependent pathways in Caenorhabditis elegans

Plos.org 
En

by Jaeseok Park, Joshua D. Meisel, Dennis H. Kim

Dynamic gene expression in neurons shapes fundamental processes in the nervous systems of animals. However, how neuronal activation by different stimuli can lead to distinct transcriptional responses is not well understood. We have been studying how microbial metabolites modulate gene expression in chemosensory neurons of Caenorhabditis elegans. Considering the diverse environmental stimuli that can activate chemosensory neurons of C. elegans... Читать дальше...

Endogenization and excision of human herpesvirus 6 in human genomes

Plos.org 
En

by Xiaoxi Liu, Shunichi Kosugi, Rie Koide, Yoshiki Kawamura, Jumpei Ito, Hiroki Miura, Nana Matoba, Motomichi Matsuzaki, Masashi Fujita, Anselmo Jiro Kamada, Hidewaki Nakagawa, Gen Tamiya, Koichi Matsuda, Yoshinori Murakami, Michiaki Kubo, Amr Aswad, Kei Sato, Yukihide Momozawa, Jun Ohashi, Chikashi Terao, Tetsushi Yoshikawa, Nicholas F. Parrish, Yoichiro Kamatani

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Москва

Солнечные дети на сцене Кремля


Facilitating the propagation of spiking activity in feedforward networks by including feedback

Plos.org 
En

by Hedyeh Rezaei, Ad Aertsen, Arvind Kumar, Alireza Valizadeh

Transient oscillations in network activity upon sensory stimulation have been reported in different sensory areas of the brain. These evoked oscillations are the generic response of networks of excitatory and inhibitory neurons (EI-networks) to a transient external input. Recently, it has been shown that this resonance property of EI-networks can be exploited for communication in modular neuronal networks by enabling the transmission... Читать дальше...

In silico co-factor balance estimation using constraint-based modelling informs metabolic engineering in Escherichia coli

Plos.org 
En

by Laura de Arroyo Garcia, Patrik R. Jones

In the growing field of metabolic engineering, where cells are treated as “factories” that synthesize industrial compounds, it is essential to consider the ability of the cells’ native metabolism to accommodate the demands of synthetic pathways, as these pathways will alter the homeostasis of cellular energy and electron metabolism. From the breakdown of substrate, microorganisms activate and reduce key co-factors such as ATP and NAD(P)H, which subsequently need to be hydrolysed and oxidized... Читать дальше...


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