by Enrico Ferrero, Sophie Brachat, Jeremy L. Jenkins, Philippe Marc, Peter Skewes-Cox, Robert C. Altshuler, Caroline Gubser Keller, Audrey Kauffmann, Erik K. Sassaman, Jason M. Laramie, Birgit Schoeberl, Mark L. Borowsky, Nikolaus Stiefl
by Saurav Mallik, Dan S. Tawfik
Oligomeric proteins are central to life. Duplication and divergence of their genes is a key evolutionary driver, also because duplications can yield very different outcomes. Given a homomeric ancestor, duplication can yield two paralogs that form two distinct homomeric complexes, or a heteromeric complex comprising both paralogs. Alternatively, one paralog remains a homomer while the other acquires a new partner. However, so far, conflicting trends have been noted with respect to which fate dominates... Читать дальше...
by Quynh-Anh Nguyen, John Rinzel, Rodica Curtu
A repeating triplet-sequence ABA− of non-overlapping brief tones, A and B, is a valued paradigm for studying auditory stream formation and the cocktail party problem. The stimulus is “heard” either as a galloping pattern (integration) or as two interleaved streams (segregation); the initial percept is typically integration then followed by spontaneous alternations between segregation and integration, each being dominant for a few seconds. The probability of segregation grows over seconds... Читать дальше...
by Ondrej Maxian, Alex Mogilner, Wanda Strychalski
Cell migration through a three-dimensional (3D) extracellular matrix (ECM) underlies important physiological phenomena and is based on a variety of mechanical strategies depending on the cell type and the properties of the ECM. By using computer simulations of the cell’s mid-plane, we investigate two such migration mechanisms—‘push-pull’ (forming a finger-like protrusion, adhering to an ECM node, and pulling the cell body forward) and ‘rear-squeezing’... Читать дальше...
by Carolyn Coyne, Jimmy D. Ballard, Ira J. Blader
The SARS-CoV-2 epidemic challenged universities and other academic institutions to rapidly adapt to urgent and life-threatening situations. It forced most institutions to shut down nearly every aspect of their research and educational enterprises. In doing so, university leaders were thrust into unchartered waters and forced them to make unprecedented decisions. Successes and failures along the way highlighted how the autonomous nature of... Читать дальше...
EastEnders bosses have found clever hacks to get around filming kissing scenes safely - and will use actors' partners to help out on set while observing social distancing rules
EASTENDERS bosses have revealed 12 massive spoilers ahead of the soap’s return next month. The BBC soap has been off screens for three months due to the pandemic and ended with Sharon Watts and Ian Beale taking control of the Queen Vic. It returns to screens on September 7 and there are some explosive plots […]