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Новости за 30.03.2022

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Different planning policies for the initial movement velocity depending on whether the known uncertainty is in the cursor or in the target: Motor planning in situations where two potential movement distances exist

Plos.org 
En

by Ryoji Onagawa, Kae Mukai, Kazutoshi Kudo

During goal-directed behaviors, individuals can be required to start a movement before deciding on the final goal. Previous studies have focused on the initial movement direction in situations involving multiple targets in different directions from the starting position and have shown that the movement is initiated in the average direction among the target directions. However, the previous studies only included situations with targets at equivalent distances... Читать дальше...

Research on extremely short construction period of engineering project based on labor balance under resource tolerance

Plos.org 
En

by Junlong Peng, Mengyao Wang, Chao Peng, Ke Hu

Under the condition of resource tolerance, engineering construction projects face the problem of labor force balance in the working face. Notably, a deviation occurs between the distribution and certain demand of the labor force in the limited working face, which affects the realization of an extremely short construction period. To address this problem, we first introduced the stochastic coefficient of labor force equilibrium to measure the degree of labor balance. Читать дальше...

A feature transferring workflow between data-poor compounds in various tasks

Plos.org 
En

by Xiaofei Sun, Jingyuan Zhu, Bin Chen, Hengzhi You, Huiqing Xu

Compound screening by in silico approaches has advantages in identifying high-activity leading compounds and can predict the safety of the drug. A key challenge is that the number of observations of drug activity and toxicity accumulation varies by target in different datasets, some of which are more understudied than others. Owing to an overall insufficiency and imbalance of drug data, it is hard to accurately predict drug activity... Читать дальше...

Efficiency of antioxidant Avenanthramide-C on high-dose methotrexate-induced ototoxicity in mice

Plos.org 
En

by Alphonse Umugire, Youngmi Choi, Sungsu Lee, Hyong-Ho Cho

Methotrexate (MTX) has been used in treating various types of cancers but can also cause damage to normal organs and cell types. Folinic acid (FA) is a well-known MTX antidote that protects against toxicity caused by the drug and has been used for decades. Since hearing loss caused by MTX treatment is not well studied, herein we aimed to investigate the efficiency of the antioxidant Avenanthramide-C (AVN-C) on high-dose MTX (HDMTX)... Читать дальше...



Transition from undergraduates to residents: A SWOT analysis of the expectations and concerns of Japanese medical graduates during the COVID-19 pandemic

Plos.org 
En

by Mikio Hayashi, Katsumi Nishiya, Kazunari Kaneko

Introduction

Interruptions in undergraduate clinical clerkship during the COVID-19 pandemic have reduced the confidence and preparedness of residents beginning their postgraduate training. We explore the thoughts of new residents about this transition and reflect on the support needed.

Methods

An exploratory qualitative case study was conducted with 51 residents. All had experienced interruptions in clinical training due to the pandemic... Читать дальше...

Model for establishing a new liver transplantation center through mentorship from a university with transplantation expertise

Plos.org 
En

by Rafael Soares Pinheiro, Wellington Andraus, Fernando Gomes Romeiro, Rodrigo Bronze de Martino, Liliana Ducatti, Rubens Macedo Arantes, Leonardo Pelafsky, Claudia Nishida Hasimoto, Fabio da Silva Yamashiro, Lucas Souto Nacif, Luciana Bertocco de Paiva Haddad, Vinicius Rocha Santos, Daniel Reis Waisberg, Matheus Fachini Vane, Joel Avancini Rocha-Filho, Walmar Kerche de Oliveira, Luiz Augusto Carneiro-D’Albuquerque

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Москва

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