by The PLOS ONE Editors
by Alex P. Salam, Alexandre Duvignaud, Marie Jaspard, Denis Malvy, Miles Carroll, Joel Tarning, Piero L. Olliaro, Peter W. Horby
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by Gláucia Elisete Barbosa Marcon, Juliana de Jesus Guimarães Ferreira, Eros Antonio de Almeida, Adriane Maira Delicio, Mariane Barroso Pereira, Jamiro da Silva Wanderley, Luiz Cláudio Martins, Paula Durante Andrade, Rodrigo Gonçalves de Lima, Sandra Cecília Botelho Costa
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by Jana Zernant, Winston Lee, Jun Wang, Kerry Goetz, Ehsan Ullah, Takayuki Nagasaki, Pei-Yin Su, Gerald A. Fishman, Stephen H. Tsang, Santa J. Tumminia, Brian P. Brooks, Robert B. Hufnagel, Rui Chen, Rando Allikmets
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by Xinxin Peng, Yikai Luo, Hongyue Li, Xuejiao Guo, Hu Chen, Xuwo Ji, Han Liang
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by João Pedro Fonseca, Elham Aslankoohi, Andrew H. Ng, Michael Chevalier
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by Yi Wang, Stephanie C. Hicks, Kasper D. Hansen
Estimates of correlation between pairs of genes in co-expression analysis are commonly used to construct networks among genes using gene expression data. As previously noted, the distribution of such correlations depends on the observed expression level of the involved genes, which we refer to this as a mean-correlation relationship in RNA-seq data, both bulk and single-cell. This dependence introduces an unwanted technical bias in co-expression... Читать дальше...
by Daniele Proverbio, Françoise Kemp, Stefano Magni, Jorge Gonçalves
Developing measures for rapid and early detection of disease re-emergence is important to perform science-based risk assessment of epidemic threats. In the past few years, several early warning signals (EWS) from complex systems theory have been introduced to detect impending critical transitions and extend the set of indicators. However, it is still debated whether they are generically applicable or potentially sensitive... Читать дальше...
by Nicolas Franco, Pietro Coletti, Lander Willem, Leonardo Angeli, Adrien Lajot, Steven Abrams, Philippe Beutels, Christel Faes, Niel Hens
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by Lei Wang, Jiangguo Zhang, Dali Wang, Chen Song
One of the unique traits of membrane proteins is that a significant fraction of their hydrophobic amino acids is exposed to the hydrophobic core of lipid bilayers rather than being embedded in the protein interior, which is often not explicitly considered in the protein structure and function predictions. Here, we propose a characteristic and predictive quantity, the membrane contact probability (MCP), to describe the likelihood of the amino... Читать дальше...
by Michael F. Staddon, Edwin M. Munro, Shiladitya Banerjee
The actin cortex is an active adaptive material, embedded with complex regulatory networks that can sense, generate, and transmit mechanical forces. The cortex exhibits a wide range of dynamic behaviours, from generating pulsatory contractions and travelling waves to forming organised structures. Despite the progress in characterising the biochemical and mechanical components of the actin cortex, the emergent dynamics of this mechanochemical system is poorly understood. Читать дальше...
by Anthony Burnetti, William C. Ratcliff
In a new paper published in PLOS Biology, Dudin and colleagues evolve simple multicellularity in Sphaeroforma arctica, a unicellular relative of animals. This work establishes a new and open-ended avenue for examining the evolution of multicellularity in an important but understudied group of organisms. This Primer explores the implications of a new PLOS Biology study in which the authors evolve simple multicellularity in Sphaeroforma arctica, a unicellular... Читать дальше...
by Giulio Di Minin, Markus Holzner, Alice Grison, Charles E. Dumeau, Wesley Chan, Asun Monfort, Loydie A. Jerome-Majewska, Henk Roelink, Anton Wutz
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Former flyweight champion Brandon Moreno at the UFC 270 presser. | Photo by Chris Unger/Zuffa LLC
Brandon Moreno airs his side of the current back-and-forth with UFC champion Deiveson Figueiredo.
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I’ve served as a host at several different restaurants, and in every position, scripted greetings were a part of the job. Sometimes in my sleep I still recite the phrase “we’ll shoot you a text when your table is ready, and in the meantime feel free to get the party started at the bar!” And while there’s nothing…
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TL;DR: On March 30 at 11 a.m. ET, Amazon Prime members will have the opportunity to secure a PlayStation 5 Digital Edition console during the merchant's limited restock. Just refresh your browser when the stock drops and hope that you're one of the lucky few.
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Haney is set to fight for the undisputed lightweight title in Australia. | Photo by Louis Grasse/PxImages/Icon Sportswire via Getty Images
Haney discusses his upcoming undisputed lightweight unification with Kambosos.
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The fifth review of the trade policies and practices of Pakistan takes place on 30 March and 1 April 2022. The basis for the review is a report by the WTO Secretariat and a report by the Government of Pakistan.
How many ports do you need? What does 4K UHD even mean? Here's everything you need to know.
Samsung has officially unveiled its 2022 class of Neo QLED, OLED, and lifestyle TVs. Here's everything you need to know about what's in store this year and when you can get your hands on a new model.
This article includes information about the costs for failing to solve organization diversity issues and the simple tactics that can resolve them.