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Новости за 01.06.2022

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Treatment failure, death, and predictors among PLWHIV on second-line antiretroviral therapy in Dessie Comprehensive Specialized Hospital, northeast Ethiopia: A retrospective cohort study

Plos.org 
En

by Shambel Wedajo, Getu Degu, Amare Deribew, Fentie Ambaw

Background

The proportion of HIV patients on second-line antiretroviral therapy is becoming a growing public health concern, especially in a low-income country setting. However, unlike first-line therapy, to date, very little is known about the outcomes of second-line therapy in the Ethiopia context. Thus, this study was conducted to determine the rate of treatment failure, death, and their predictors among HIV patients receiving second-line therapy. Читать дальше...



Bidirectional convolutional LSTM for the prediction of nitrogen dioxide in the city of Madrid

Plos.org 
En

by Ditsuhi Iskandaryan, Francisco Ramos, Sergio Trilles

Nitrogen dioxide is one of the pollutants with the most significant health effects. Advanced information on its concentration in the air can help to monitor and control further consequences more effectively, while also making it easier to apply preventive and mitigating measures. Machine learning technologies with available methods and capabilities, combined with the geospatial dimension, can perform predictive analyses with higher accuracy and... Читать дальше...

Reach adaption to a visuomotor gain with terminal error feedback involves reinforcement learning

Plos.org 
En

by Tsuyoshi Ikegami, J. Randall Flanagan, Daniel M. Wolpert

Motor adaptation can be achieved through error-based learning, driven by sensory prediction errors, or reinforcement learning, driven by reward prediction errors. Recent work on visuomotor adaptation has shown that reinforcement learning leads to more persistent adaptation when visual feedback is removed, compared to error-based learning in which continuous visual feedback of the movement is provided. However, there is evidence that... Читать дальше...

Efficacy of rupatadine in reducing the incidence of dengue haemorrhagic fever in patients with acute dengue: A randomised, double blind, placebo-controlled trial

Plos.org 
En

by Gathsaurie Neelika Malavige, Chandima Jeewandara, Ananda Wijewickrama, Dumni Gunasinghe, Sameera D. Mahapatuna, Chathurika Gangani, Vimalahan Vimalachandran, Geethal Jayaratne, Yashoda Perera, Chandanie Wanigatunga, Harsha Dissanayake, Shamini Prathapan, Eranga Narangoda, Damayanthi Idampitiya, Laksiri Gomes, Samurdhi Wickramanayake, Pramodth Sahabandu, Graham S. Ogg

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Новости России

Improved transcriptome assembly using a hybrid of long and short reads with StringTie

Plos.org 
En

by Alaina Shumate, Brandon Wong, Geo Pertea, Mihaela Pertea

Short-read RNA sequencing and long-read RNA sequencing each have their strengths and weaknesses for transcriptome assembly. While short reads are highly accurate, they are rarely able to span multiple exons. Long-read technology can capture full-length transcripts, but its relatively high error rate often leads to mis-identified splice sites. Here we present a new release of StringTie that performs hybrid-read assembly. By taking... Читать дальше...

Why does viral RNA sometimes persist after recovery from acute infections?

Plos.org 
En

by Diane E. Griffin

DNA viruses often persist in the body of their host, becoming latent and recurring many months or years later. By contrast, most RNA viruses cause acute infections that are cleared from the host as they lack the mechanisms to persist. However, it is becoming clear that viral RNA can persist after clinical recovery and elimination of detectable infectious virus. This persistence can either be asymptomatic or associated with late progressive disease or nonspecific lingering symptoms... Читать дальше...


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