SILVI, an open-source pipeline for T-cell epitope selection
by Joana Pissarra, Franck Dorkeld, Etienne Loire, Vincent Bonhomme, Denis Sereno, Jean-Loup Lemesre, Philippe Holzmuller
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by Joana Pissarra, Franck Dorkeld, Etienne Loire, Vincent Bonhomme, Denis Sereno, Jean-Loup Lemesre, Philippe Holzmuller
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by Zeshu Yu, Shin-ichi Ito, Marty Kwok-Shing Wong, Susumu Yoshizawa, Jun Inoue, Sachihiko Itoh, Ryuji Yukami, Kazuo Ishikawa, Chenying Guo, Minoru Ijichi, Susumu Hyodo
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by Tristan Millington
When studying financial markets, we often look at estimating a correlation matrix from asset returns. These tend to be noisy, with many more dimensions than samples, so often the resulting correlation matrix is filtered. Popular methods to do this include the minimum spanning tree, planar maximally filtered graph and the triangulated maximally filtered graph, which involve using the correlation network as the adjacency matrix of a graph and then using tools from graph theory. Читать дальше...
by Geissy Lainny de Lima-Araujo, Geovan Menezes de Sousa Júnior, Thatiane Mendes, Marcelo Demarzo, Norman Farb, Draulio Barros de Araujo, Maria Bernardete Cordeiro de Sousa
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by Fátima Velásquez-Rojas, Jesus E. Fajardo, Daniela Zacharías, María Fabiana Laguna
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by Jette Bloemberg, Fabian Trauzettel, Bram Coolen, Dimitra Dodou, Paul Breedveld
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by Umair Muneer Butt, Sukumar Letchmunan, Fadratul Hafinaz Hassan, Tieng Wei Koh
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by Jae-Chan Ryu, Jae-Han Bae, Sang Hee Ha, Jun Young Chang, Dong-Wha Kang, Sun U. Kwon, Jong S. Kim, Chung Hee Baek, Bum Joon Kim
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by Mohammad Movahedi, Angela Cesta, Xiuying Li, Claire Bombardier, OBRI investigators
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by Edem Gavor, Yeu Khai Choong, Yonghao Liu, Julien Pompon, Eng Eong Ooi, Yu Keung Mok, Haiyan Liu, R Manjunatha Kini, J. Sivaraman
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by Stephen R. Proulx, Henrique Teotónio
Gene flow between populations adapting to differing local environmental conditions might be costly because individuals can disperse to habitats where their survival is low or because they can reproduce with locally maladapted individuals. The amount by which the mean relative population fitness is kept below one creates an opportunity for modifiers of the genetic architecture to spread due to selection. Prior work that separately considered modifiers changing dispersal... Читать дальше...
by Perinthottathil Sreejith, Sumira Malik, Changsoo Kim, Benoît Biteau
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by Shaobo Li, Charleston W. K. Chiang, Swe Swe Myint, Katti Arroyo, Tsz Fung Chan, Libby Morimoto, Catherine Metayer, Adam J. de Smith, Kyle M. Walsh, Joseph L. Wiemels
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by Fredrik Orädd, Jonas Hyld Steffen, Pontus Gourdon, Magnus Andersson
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by Ran Su, Haitang Yang, Leyi Wei, Siqi Chen, Quan Zou
Drug-induced toxicity damages the health and is one of the key factors causing drug withdrawal from the market. It is of great significance to identify drug-induced target-organ toxicity, especially the detailed pathological findings, which are crucial for toxicity assessment, in the early stage of drug development process. A large variety of studies have devoted to identify drug toxicity. However, most of them are limited to single organ or only binary toxicity. Читать дальше...
by Alex M. Casella, Carlo Colantuoni, Seth A. Ament
Genetic risk for complex traits is strongly enriched in non-coding genomic regions involved in gene regulation, especially enhancers. However, we lack adequate tools to connect the characteristics of these disruptions to genetic risk. Here, we propose RWAS (Regulome Wide Association Study), a new application of the MAGMA software package to identify the characteristics of enhancers that contribute to genetic risk for disease. RWAS involves three steps... Читать дальше...
by Pierrick Le Borgne, Logan Greibill, Marine Hélène Laporte, Michel Lemullois, Khaled Bouhouche, Mebarek Temagoult, Olivier Rosnet, Maeva Le Guennec, Laurent Lignières, Guillaume Chevreux, France Koll, Virginie Hamel, Paul Guichard, Anne-Marie Tassin
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by David Whitney, Mauro Manassi, Yuki Murai
Identifying the neural correlates of visual serial dependence has lagged behind the behavioral understanding. A new study in PLOS Biology provides a model of interpreting the complex relationship between physiology and behavior in studies of serial dependence. Our senses are barraged with discontinuous and uncertain visual input, but the brain smooths experience by making perception serially dependent. Neural correlates of this have been elusive... Читать дальше...
by Sergio Hidalgo, Joanna C. Chiu
Animals adapt their seasonal physiology by measuring photoperiodic changes over the calendar year. A new study in PLOS Biology uncovers changes in glutamate dynamics in the bean bug that are dependent on photoperiod and a clock gene. Animals adapt their seasonal physiology by measuring photoperiodic changes over the calendar year, but the neuronal mechanisms conveying this information are unclear. This Primer explores a new PLOS Biology study that sheds... Читать дальше...If brands want to see themselves in the Big Game, they better move fast. Two months after Fox wrapped its upfront negotiations, the company revealed that its Super Bowl 57 ad inventory is nearly gone, with 95% of its in-game inventory already sold five months before the event. Fox's ad sales team sold the majority...
Microsoft’s PowerToys has a new utility that lets you copy text from images: If someone sends you a picture of their business card or a screenshot of their bank account details, you can use PowerToys to quickly copy it on Windows. The new utility is called Text Extractor, and it’s available with PowerToys’ 0.62…
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Do you remember Maslow’s Hierarchy of Needs from college? It’s that pyramid of things that humans need, physiologically or psychologically, to survive. Sure, Maslow himself never imagined the hierarchy, instead preferring to see all needs as, well, needed, but we can spin the idea into something useful to us:…
Читать дальше...Take one of six public elevators to the top floor of Multnomah County’s new $324.5 million courthouse, and you’ll discover what its judicial workers and criminally accused likely already know: One of the best views of Portland belongs to the people.
My mother had me despite misgivings, and I’m still feeling the reverberations today.
Here's what to expect if you claim Social Security before reaching your full retirement age.