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Новости за 24.04.2024

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A phylogenetic method linking nucleotide substitution rates to rates of continuous trait evolution

24.04.2024 17:00

Plos.org

by Patrick Gemmell, Timothy B. Sackton, Scott V. Edwards, Jun S. Liu

Genomes contain conserved non-coding sequences that perform important biological functions, such as gene regulation. We present a phylogenetic method, PhyloAcc-C, that associates nucleotide substitution rates with changes in a continuous trait of interest. The method takes as input a multiple sequence alignment of conserved elements, continuous trait data observed in extant species, and a background phylogeny and substitution process. Читать дальше...

Validity conditions of approximations for a target-mediated drug disposition model: A novel first-order approximation and its comparison to other approximations

24.04.2024 17:00

Plos.org

by Jong Hyuk Byun, Hye Seon Jeon, Hwi-yeol Yun, Jae Kyoung Kim

Target-mediated drug disposition (TMDD) is a phenomenon characterized by a drug’s high-affinity binding to a target molecule, which significantly influences its pharmacokinetic profile within an organism. The comprehensive TMDD model delineates this interaction, yet it may become overly complex and computationally demanding in the absence of specific concentration data for the target or its complexes. Consequently, simplified... Читать дальше...

YeeD is an essential partner for YeeE-mediated thiosulfate uptake in bacteria and regulates thiosulfate ion decomposition

24.04.2024 17:00

Plos.org

by Mai Ikei, Ryoji Miyazaki, Keigo Monden, Yusuke Naito, Azusa Takeuchi, Yutaro S. Takahashi, Yoshiki Tanaka, Keina Murata, Takaharu Mori, Muneyoshi Ichikawa, Tomoya Tsukazaki

Offering Your Valuable Knowledge and Services For Free Comes at a Price — Here's How to Avoid Paying It.

24.04.2024 17:00

Entrepreneur.com

Passionate entrepreneurs can have a hard time putting monetary value to their work. They can even undervalue it at times, especially when their focus is on purpose over profit — but profit is the only way you can continue your purpose. Here's how you can build a balance between generosity and professional valuation instead.

How Investing in This Unorthodox Business Strategy Can Produce Strategic Results

24.04.2024 17:00

Entrepreneur.com

Going against the grain of conventional thinking can often lead to significant business wins. At Anago Cleaning Systems, leaning into one factor during economic downturns has proven a sucessful long-term strategy.

3 Types of Creative Blocks, and How to Overcome Them

24.04.2024 17:00

Entrepreneur.com

Science can help you understand the walls you're running into, when you struggle to start or finish a project.

The Best Free Plans for Your DIY Backyard Projects

24.04.2024 17:00

Lifehacker.com

Tackle your next backyard build with these free plans.

Home Depot's New Halloween Collection Brings Back All Your Giant-Sized Skeletal Friends

24.04.2024 17:00

Earther.com

It’s just about halfway to Halloween and Home Depot is ready to start rolling out spooky season decor to celebrate. The store’s most viral release—Skelly, the 12-foot skeleton—is consistently hard to find as the holiday gets closer, so with that in mind the popular must-have will be released early as part of this drop.

Humane review: The world is awful, and so is this family

24.04.2024 17:00

Avclub.com

One day, should humanity be blessed enough to continue upon its current collective perch, the old op-ed pages of national newspapers will provide their own records of our social temperature in these charged times. Future generations, then, will get to judge—perhaps harshly—the nature of our collective preoccupations.

‘Stellar Blade’ review: A solid Soulslike with a throwback feel

24.04.2024 17:00

Rappler.com

Don’t let the 'Bayonetta' and 'Nier' comparisons fool you, 'Stellar Blade's' combat borrows a lot from Soulslikes. Check out our review!

Exclusive: ‘My Lady Jane’ is Your New Fave Historical Romance and These First-Look Photos Prove It

24.04.2024 17:00

Cosmopolitan.com

We're just gonna let the first pic speak for itself...

‘I still regret that’ – Former Spurs midfielder admits he left the club ‘too soon’

24.04.2024 17:00

TheSpursWeb

Rafael Van der Vaart has said that the Tottenham team he played in was one of the best units he had been part of in...

Home Depot's upgraded 12-foot skeleton and its new pet dog will debut this Thursday

24.04.2024 17:00

Mashable

Home Depot will drop an upgraded 12-foot skeleton, a new skeleton dog, and other Halloween products this week as part of a limited "Halfway to Halloween" sale.

Stellar Blade review: An exhilarating spectacle that sometimes gets tedious

24.04.2024 17:00

Mashable

While 'Stellar Blade' comes off a bit predictable, the cast of characters are a delight and the excellent worldbuilding makes the game worth experiencing.

Stellar Blade on PS5 has flash and fun but is mostly dull

24.04.2024 17:00

The Verge

Image: Shift Up

While the combat is challenging and rewarding, it takes far too long to get to the good stuff.

Black Panther Party Leader Evades the FBI in Apple TV+ Caper The Big Cigar — Watch Trailer

24.04.2024 17:00

TVLine.com

Black Panther Party co-founder Huey P. Newton (played by Moonlight’s André Holland) is a wanted man in the upcoming caper The Big Cigar, premiering with the first two episodes Friday, May 17 on Apple TV+. New episodes will stream weekly through June 14. A new trailer for the six-episode limited series previews Newton’s daring escape […]

Baltimore Calls Bridge Collapse Result of Shipowners’ ‘Carelessness, Negligence’

24.04.2024 17:00

SourcingJournal.com

Baltimore's mayor and city council are seeking legal action against the owner and operator of the Dali after it crashed into the Key Bridge.

'Secondhand Embarrassment': Kim Zolciak's Daughter Ariana Slams 'RHOA' Star For Instagram Post Suggesting Ex Kroy Biermann Died

24.04.2024 17:00

The National Enquirer

The reality star's daughter went OFF about her mom's decision to imply Kroy had passed.

Poppy Montgomery’s Landlord Demands ‘Without a Trace’ Star Be Evicted From $4 Million Beach Mansion, Using Texts as Evidence in Trial

24.04.2024 17:00

The National Enquirer

The landlord says she will be using text messages as evidence in the upcoming trial.

Новости России

Москва

Путин: артисты из стран БРИКС подтвердили участие в «Интервидении»

‘But they want to sell us Nissan’: Nissan workers are asked what kind of car they drive. They say everything but Nissan

24.04.2024 17:00

The Daily Dot

Charlotte-based Nissan saleswoman Martina (@marsthustles) asked her co-worker, one-by-one, what type of car they drive and how much their car payment is. Their collective responses stunned viewers.

Manor Lords early access review: a sturdy and immersive builder that feels incomplete yet alive with promise

24.04.2024 17:00

Rock Paper Shotgun

When, in town building simulation Manor Lords, you erect your first manor, it feels natural to place it in the center of your humble 14th century European settlement. It presents as a locus of power, where your character avatar resides. Also, it’s right there in the title. I built mine down a side road, between oxen posts and granaries, for no real reason but free space. The more I play, the more it feels a fitting place. Not sidelined, exactly, just not especially loud. I need the taxes it brings to pay mercenaries to see off bandits... Читать дальше...