Pulmonary Vein Isolation and Left Atrial Appendage Ligation in Atrial Fibrillation—Reply
In Reply Drs Xia and Su raise several queries about our study, the aMAZE trial. First, they state, “The study did not assess left atrial appendage electrical isolation, which is important considering the mechanism of action of the intervention,” implying this affected outcomes. The proposed mechanism of action of LAA ligation as adjunctive therapy to PVI was 2-fold: LAA electrical isolation and left atrial volume (LAV) reduction. LAA ligation results in LAA ischemic necrosis, atrophy, and resorption, analogous to amputation. Читать дальше...