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Новости за 28.10.2024

Competitive plasticity to reduce the energetic costs of learning

Plos.org 

by Mark C. W. van Rossum, Aaron Pache

The brain is not only constrained by energy needed to fuel computation, but it is also constrained by energy needed to form memories. Experiments have shown that learning simple conditioning tasks which might require only a few synaptic updates, already carries a significant metabolic cost. Yet, learning a task like MNIST to 95% accuracy appears to require at least 108 synaptic updates. Therefore the brain has likely evolved to be able to learn using as little energy as possible. Читать дальше...

Reinforcement learning when your life depends on it: A neuro-economic theory of learning

Plos.org 

by Jiamu Jiang, Emilie Foyardg, Mark C. W. van Rossumg

Synaptic plasticity enables animals to adapt to their environment, but memory formation can require a substantial amount of metabolic energy, potentially impairing survival. Hence, a neuro-economic dilemma arises whether learning is a profitable investment or not, and the brain must therefore judiciously regulate learning. Indeed, in experiments it was observed that during starvation, Drosophila suppress formation of energy-intensive aversive memories. Читать дальше...

Mcadet: A feature selection method for fine-resolution single-cell RNA-seq data based on multiple correspondence analysis and community detection

Plos.org 

by Saishi Cui, Sina Nassiri, Issa Zakeri

Single-cell RNA sequencing (scRNA-seq) data analysis faces numerous challenges, including high sparsity, a high-dimensional feature space, and biological noise. These challenges hinder downstream analysis, necessitating the use of feature selection methods to identify informative genes, and reduce data dimensionality. However, existing methods for selecting highly variable genes (HVGs) exhibit limited overlap and inconsistent clustering performance across benchmark datasets. Читать дальше...

The future of quantum technologies for brain imaging

Plos.org 

by Daniele Faccio

The neurosciences have pioneered the use of quantum technologies for sensing and imaging the brain. Next-generation technologies promise routes towards low-cost, wearable imaging devices with high spatial and temporal resolution. The neurosciences have pioneered the use of quantum technologies for sensing and imaging the brain. This Perspective discusses next-generation technologies that promise low-cost, wearable imaging devices with high spatial and temporal resolution.

Monitoring of activity-driven trafficking of endogenous synaptic proteins through proximity labeling

Plos.org 

by Carlos Pascual-Caro, Jaime de Juan-Sanz

To enable transmission of information in the brain, synaptic vesicles fuse to presynaptic membranes, liberating their content and exposing transiently a myriad of vesicular transmembrane proteins. However, versatile methods for quantifying the synaptic translocation of endogenous proteins during neuronal activity remain unavailable, as the fast dynamics of synaptic vesicle cycling difficult specific isolation trafficking proteins during such a transient surface exposure. Читать дальше...



The expanding horizon of neurotechnology: Is multimodal neuromodulation the future?

Plos.org 

by Silvestro Micera, Guglielmo Foffani

The clinical applications of neurotechnology are rapidly expanding, and the combination of different approaches could be more effective and precise to treat brain disorders. This Perspective discusses the potential and challenges of “multimodal neuromodulation,” which combines modalities such as electrical, magnetic, and ultrasound stimulation. The clinical applications of neurotechnology are rapidly expanding, and the combination of different approaches... Читать дальше...

Ethical considerations for the use of brain–computer interfaces for cognitive enhancement

Plos.org 

by Emma C. Gordon, Anil K. Seth

Brain–computer interfaces (BCIs) enable direct communication between the brain and external computers, allowing processing of brain activity and the ability to control external devices. While often used for medical purposes, BCIs may also hold great promise for nonmedical purposes to unlock human neurocognitive potential. In this Essay, we discuss the prospects and challenges of using BCIs for cognitive enhancement, focusing specifically on invasive enhancement BCIs (eBCIs). Читать дальше...

Meeting final six FATF action items a ‘difficult challenge’ – Treasury

Engineeringnews.co.za 

National Treasury has welcomed the progress made by all agencies in ensuring South Africa now meets 16 of the 22 action items required for the country to exit the Financial Action Task Force (FATF) grey list. Only six action items remain and, while South Africa is working hard to address all outstanding action items by February 2025, “this remains a difficult challenge”, Treasury cautions.

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