Elevating levels of the endocannabinoid 2-arachidonoylglycerol blunts opioid reward but not analgesia | Science Advances
Enhancing endocannabinoid 2-AG levels in the VTA blunts opioid reward and associated NAc activity and dopamine release.
Enhancing endocannabinoid 2-AG levels in the VTA blunts opioid reward and associated NAc activity and dopamine release.
A receptor-like kinase controls cell wall biosynthesis under salt stress by regulating microtubule organization.
PLCγ2 structures revealed conformational flexibility of key regulatory domains and found regions involved in autoinhibition.
Dynamic evolution of local chemical order enables prominent mechanical properties of alloys at ambient-to-cryogenic temperatures.
T cell receptor–centric perspective improves single-cell analysis.
A photosystem I structure binding plastoquinone in its electron transfer chain reveals insight into photosynthesis bioenergetics.
N-cadherin inhibition prevents airway obstruction in allergic asthma models and elicits bronchodilation.
A superconducting state with partial spin polarization is enabled by the binding of electron pairs and magnons.
An anchored active polymer can spontaneously form knots, providing an efficient way to engineer the topology of macromolecules.
A nanosized covalent organic framework (nCOF)–based pyroelectric catalyst was engineered for effective pyroelectroimmunotherapy.
An alternative berberine biosynthetic pathway from Phellodendron reveals its convergent evolution among divergent lineages.
Multifunctional organic-inorganic molecular ferroelectric composites enable visual-tactile–fused encrypted interfaces.
Investment in downstream beneficiation is starting to pay dividends and to show real commercial results, says Tharisa CEO Phoevos Pouroulis. “We sold our first commercial chrome alloy to an industrial user in South Africa and this really is the first step in a journey that sees us diversifying our product mix and allowing us to beneficiate our product in a unique proprietary way that opens up new markets, for our chrome business,” Pouroulis adds.
Small Business Saturday, other promotions aim to drive traffic to local retailers.
(Telecompaper) Italian operator Fastweb has made available a new online platform to raise awareness of the conscious use of digital technology...
Metasurfaces have introduced new opportunities in photonic design by offering unprecedented, nanoscale control over optical wavefronts. These artificially structured layers have largely been used to passively manipulate the flow of light by controlling ...
Stem cells perceive and respond to biochemical and physical signals to maintain homeostasis. Yet, it remains unclear how stem cells sense mechanical signals from their niche in vivo. In this work, we investigated the roles of PIEZO mechanosensitive ...
Alzheimer’s disease (AD) and other age-related disorders associated with demyelination exhibit sex differences. In this work, we used single-nuclei transcriptomics to dissect the contributions of sex chromosomes and gonads in demyelination and AD. In a ...
Surveillance of drug resistance and the discovery of novel targets—key objectives in the fight against malaria—rely on identifying resistance-conferring mutations in Plasmodium parasites. Current approaches, while successful, require laborious ...
Protein synthesis begins with the formation of a ribosome-messenger RNA (mRNA) complex. In bacteria, the small ribosomal subunit (30S) is recruited to many mRNAs through base pairing with the Shine-Dalgarno (SD) sequence and RNA binding by ribosomal ...
Everything you need to know in order to watch the Ole Miss Rebels take on the Mississippi State Bulldogs on Friday, Nov. 29.
Full marks to the belayer for not taking their hand off the rope.
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NEWS – The holidays are the perfect opportunity to treat yourself while shopping for gifts for loved ones. From charging cables to adapters and other handy accessories, stocking up on tech essentials is a smart move when they’re discounted. This Black Friday, UGREEN is rolling out an impressive deal lineup covering all your charging needs. […]
While not the main focus of most games, side bets appeal to gamblers who enjoy the possibility of turning a small risk into a significant win.
The stock market was shut down on Thanksgiving in observance of the federal holiday, so what are its hours for Black Friday?