Dynamic responses of striatal cholinergic interneurons control behavioral flexibility | Science Advances
Striatal cholinergic interneurons dynamically control the extinction and updating of goal-directed learning.
Striatal cholinergic interneurons dynamically control the extinction and updating of goal-directed learning.
Data-driven controller enables real-time assistance modulation by accurately estimating both the user and the environment states.
Smart covalent organic framework membranes are developed to transform the organic solvent nanofiltration technology.
Plastic-binding peptides that can serve as microplastic remediation tools are designed with a quantum computer.
CRISPR activation therapy offers a mutation-independent method to restore vision in genetic eye diseases.
Cryo-EM, electrophysiology, and MD simulations reveal the basis for pH sensitivity and biphasic Zn2+ modulation of GlyRα3.
Precise control of cation charges in superlattices via charge transfer offers insight for designing functional heterostructures.
Mechanical forces felt by cancer cells tune how small-molecule chemotherapy enters their nuclei.
A thermodynamically guided alloy synthesis paradigm directly turns oxides into sustainable bulk nanostructured porous alloys.
Multimodal microrobot with passively morphing wheels offers excellent maneuverability, low power consumption, and high robustness.
A detector-grade perovskite crystal with uniform domain orientation exhibits high energy resolution in spectroscopic detectors.
Corneal epithelial basement membrane–inspired hydrogel provides a potential solution for corneal scarring–induced blindness.
A structural atlas of a beneficial insect virus defines a new virus realm that diversified in the Cambrian.
CRISPR-Cas13 precisely targets cancer-driving mutations with single-base accuracy, enabling tailored transcriptome editing.
PFC neural responses during contextual decision-making are consistent with both recurrent and input-driven flexible computations.
Terrestrial proxy evidence for sulfur-induced cooling event linked to Deccan Trap eruptions 30 ka before K–Pg boundary.
Optical cavities based on two-dimensional materials enable chiral response.
A light is shone on the topology and quantum geometry of magnetic topological insulators.
The microbiomes of Earth’s surface and subsurface environments are different in composition, but similar in diversity.
Ancient genomic data from the Carpathian Basin reveal discontinuities among immigrant groups during the first millennium CE.
Pregnancy leads to region-specific changes in the structure, content, and contractility of the upper and lower cervix in mice.
Machine learning–based metabolomic aging clocks predict health and death, with nonlinear models better capturing aging signals.
The 3D genome influences new gene evolution by altering gene expression via the general mechanism of enhancer capture-divergence.
Structures of PS synthase elucidate molecular and catalytic mechanism of phospholipid biosynthesis in Gram-negative bacteria.
A NiH-catalyzed radical relay strategy enables the hydroalkylation of unactivated olefins with hydrocarbons.