NR4A1 destabilizes TNF mRNA in microglia and modulates stroke outcomes

by Yao Yao

Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. A study in PLOS Biology identifies a new mechanism, through which the transcription factor NR4A1 negatively regulates TNF expression in microglia. Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. This Primer explores a PLOS Biology study that identifies a new mechanism through which the transcription factor NR4A1 negatively regulates TNF expression in microglia.