STING activation disrupts tumor vasculature to overcome the EPR limitation and increase drug deposition | Science Advances
Nanoparticle-induced STING activation disrupts tumor vasculature to overcome the EPR limitation and increase drug deposition.
Nanoparticle-induced STING activation disrupts tumor vasculature to overcome the EPR limitation and increase drug deposition.
A tetrahedral arrangement of the pseudoicosahedral core defines the architecture of the 12-MDa key mammalian multienzyme.
Increasing H content in alloy 725 reduces slip-assisted crack initiation and increases crack initiation with no nearby slip.
Electron-bifurcating reductases and fluoride exporters are implicated in reductive defluorination by Acetobacterium spp.
The activity oscillations of the DnaA protein monitored in single cells challenge classic views of the E. coli cell cycle.
Trichodesmium cyanobacteria are an overlooked source of food for larvae of the most important predator of corals.
Optical spin transfer between bulk and surface states drives ultrafast spin and magnetization dynamics in gadolinium.
Dynamic states of atomic and defect configurations are autonomously probed at the single-atom level in STEM-EELS.
An enhanced native chemical ligation by peptide conjugation in trifluoroacetic acid was developed to promote protein synthesis.
Primate-specific endogenous retroviruses can reactivate as tumor-specific enhancers in colorectal cancer.
Blue PeLEDs achieve record-high efficiencies through a minor regulation of chlorine defects, showcasing a key design principle.
Temperature-dependent emission from highly doped upconverting nanoparticles enables optical super-resolution nanothermometry.
Click3D, an optimized method for fluorescent staining with click chemistry, enables whole-organ 3D imaging of clickable probes.
Two field studies suggest that giving college students greater autonomy can improve motivation and learning.
A bimodal actuation strategy is proposed to realize individual and collective manipulation of droplets in three dimensions.
Reef fishes that receive the least research effort and public attention are at high risk of extinction.
The predominant mixotrophic growth of diatoms in the marine environment can substantially affect the global carbon cycle.
Safe anonymization and sharing of personal data will be achieved by combining formal privacy methods with red-teaming.
A comprehensive analysis of global clinical trial trends in engineered biomaterials is explored, surveying 834 studies.
What unites modern ecology, conserving threatened biodiversity, climate dynamics, the nature of early Earth, macroevolution, and the atmospheres of other planets? All fall within the remit of the Earth, Environmental, Ecological, and Space Sciences section, one of the broadest within Science Advances. The goal of the 6 deputy editors and almost 60 associate editors within our group is to help our international communities push our science forward by identifying, reviewing, and publishing the most exciting research. Читать дальше...
Календарь игр нового сезона в ВХЛ у хоккейного клуба "Югра" наконец обнародован.
УрБК, Екатеринбург, 17.07.2024. В Екатеринбурге с 22 июля по 5 августа закроют движение транспорта по улице Татищева (на участке от Плотников до Сварщиков). Ограничения связаны с реконструкцией воздушных линий электропередачи, сообщает пресс-служба горадминистрации. Объезд для автомобильного транспорта будет организован по улицам Каменщиков —Татищева — Викулова — Венгерских Коммунаров и по улицам Плотников — Нагорной — Каменщиков. Добавим, что маршруты движения общественного транспорта на этом участке не изменятся.
«Пока на прошлой неделе в Вашингтоне фестивалили по поводу 75-летия со дня рождения Североатлантического альянса, Москва, воспользовавшись расслабленностью натовцев, создавала угрозу Европе. В то время как лидеры государств-членов в коридорах базы Эндрюс три дня обсуждали человеческое и божественное значение защиты Запада, Россия действовала, – с тревогой пишет испанское издание El Confidencial. – Москва хочет воспользоваться разложившейся и деградировавшей Ливией, страной, богатой нефтью и другими природными ресурсами... Читать дальше...
В ESPN просто не любят хоккей?