by Zhaoyang Liu, Garrett W. D. Easson, Jingjing Zhao, Nadja Makki, Nadav Ahituv, Matthew J. Hilton, Simon Y. Tang, Ryan S. Gray
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by Barbara De Kegel, Colm J. Ryan
What makes a gene essential for cellular survival? In model organisms, such as budding yeast, systematic gene deletion studies have revealed that paralog genes are less likely to be essential than singleton genes and that this can partially be attributed to the ability of paralogs to buffer each other's loss. However, the essentiality of a gene is not a fixed property and can vary significantly across different genetic backgrounds. It is unclear to what extent paralogs contribute to this variation... Читать дальше...
by Igor Obuchowski, Artur Piróg, Milena Stolarska, Bartłomiej Tomiczek, Krzysztof Liberek
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by Elisa Salviato, Vera Djordjilović, Monica Chiogna, Chiara Romualdi
Topological gene-set analysis has emerged as a powerful means for omic data interpretation. Although numerous methods for identifying dysregulated genes have been proposed, few of them aim to distinguish genes that are the real source of perturbation from those that merely respond to the signal dysregulation. Here, we propose a new method, called SourceSet, able to distinguish between the primary and the secondary dysregulation... Читать дальше...
by Nicholas Franzese, Adam Groce, T. M. Murali, Anna Ritz
Characterizing cellular responses to different extrinsic signals is an active area of research, and curated pathway databases describe these complex signaling reactions. Here, we revisit a fundamental question in signaling pathway analysis: are two molecules “connected” in a network? This question is the first step towards understanding the potential influence of molecules in a pathway, and the answer depends on the choice of modeling framework. Читать дальше...
by Előd Méhes, Beáta Biri-Kovács, Dona G. Isai, Márton Gulyás, László Nyitray, András Czirók
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by Sebastian Spreizer, Ad Aertsen, Arvind Kumar
Spatio-temporal sequences of neuronal activity are observed in many brain regions in a variety of tasks and are thought to form the basis of meaningful behavior. However, mechanisms by which a neuronal network can generate spatio-temporal activity sequences have remained obscure. Existing models are biologically untenable because they either require manual embedding of a feedforward network within a random network or supervised learning to train... Читать дальше...
by Sean West, Sushil Kumar, Surinder K. Batra, Hesham Ali, Dario Ghersi
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by Jessica Planade, Reda Belbahri, Micaela Boiero Sanders, Audrey Guillotin, Olivia du Roure, Alphée Michelot, Julien Heuvingh
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by Jeff Maltas, Kevin B. Wood
Evolved resistance to one antibiotic may be associated with "collateral" sensitivity to other drugs. Here, we provide an extensive quantitative characterization of collateral effects in Enterococcus faecalis, a gram-positive opportunistic pathogen. By combining parallel experimental evolution with high-throughput dose-response measurements, we measure phenotypic profiles of collateral sensitivity and resistance for a total of 900 mutant–drug combinations. We... Читать дальше...
The best nap duration varies from person to person, but experts tend to agree that 20 minutes is ideal. Learn more about how long naps should be in this article.
The "Fast Money" traders discuss homebuilders in a low interest rate environment.
PAUL MERSON COLUMN: Our man Merse on Tottenham's underrated South Korea striker, West Ham's underperforming manager Manuel Pellegrini and Pep Guardiola's must-do January transfer business
Star man Oliver Pritchard joins the British Army in Kenya
The actress moans that selfie-takers interfere with her trips to Waitrose
EXCLUSIVE: The popular dating show sees 30 new singletons trying to find love
The sister's mother uses her real name on Strictly forums
The indie veterans insist their miserable image is a myth
Photo by James Chance/Getty Images
Conor McGregor has gone after pretty much everyone lately, so why not Loma too?
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Amitai Etzioni
Security, Middle East
U.S.-Iran relations are moving in the wrong direction.
Key point: Trump's Iran policy has not produced the ends America seeks.
Rarely are one’s predictions as quickly tested as those I made in August. I suggested that the United States’ lame response to Iran’s aggressive actions would lead to escalation. It was not hard to predict. It seemed obvious to me that, unable to get the European Union to help meaningfully circumvent U.S. sanctions... Читать дальше...
I have been keeping a PlayStation 5 wishlist for about two years. Now that Sony is starting to announce concrete details about their new console, I realize time is running out: if I’m gonna make a video about my predictions—many of which are already coming true—I gotta do it right now. So I stepped in front of the…
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Round 23
VOTE NOW
50's/60's
Nancy Sinatra ‘These Boots Are Made For Walking’ Mrs 64 7-4 Little Richard 'Good Golly Miss Molly' Bally
Cream 'Badge' Gandi 3-8 Rolling Stones 'Street Fighting Man' John
Spencer Davis Group ‘Gimme Some Lovin’ Azkal 7-4 Peter and Gordon 'World Without Love' Faaip
Beatles 'In My Life' Cat 11-0 James & Bobby Purify 'I'm Your Puppet' BB
Zombies ‘Time Of The Season’ 64 9-2 Paragons ‘The Tide is High’ Norfolk
Judy Collins 'Both Sides... Читать дальше...
Iguodala remains on the Grizzlies' roster as they seek a trade.
26 Oct 19 - 06:00