Transcriptional and genomic parallels between the monoxenous parasite Herpetomonas muscarum and Leishmania
by Megan A. Sloan, Karen Brooks, Thomas D. Otto, Mandy J. Sanders, James A. Cotton, Petros Ligoxygakis
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by Megan A. Sloan, Karen Brooks, Thomas D. Otto, Mandy J. Sanders, James A. Cotton, Petros Ligoxygakis
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by Jessica A. Lee, Siavash Riazi, Shahla Nemati, Jannell V. Bazurto, Andreas E. Vasdekis, Benjamin J. Ridenhour, Christopher H. Remien, Christopher J. Marx
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by Yongbo Xue, Joanna C. Chiu, Yong Zhang
Circadian rhythms are generated by endogenous pacemakers that rely on transcriptional-translational feedback mechanisms conserved among species. In Drosophila, the stability of a key pacemaker protein PERIOD (PER) is tightly controlled by changes in phosphorylation status. A number of molecular players have been implicated in PER destabilization by promoting PER progressive phosphorylation. On the other hand, there have been few reports describing... Читать дальше...
by Tarunendu Mapder, Sam Clifford, John Aaskov, Kevin Burrage
The titre of virus in a dengue patient and the duration of this viraemia has a profound effect on whether or not a mosquito will become infected when it feeds on the patient and this, in turn, is a key driver of the magnitude of a dengue outbreak. The assessment of the heterogeneity of viral dynamics in dengue-infected patients and its precise treatment are still uncertain. Infection onset, patient physiology and immune response... Читать дальше...
by Yichen Zheng, Thomas Wiehe
Selective sweeps, the genetic footprint of positive selection, have been extensively studied in the past decades, with dozens of methods developed to identify swept regions. However, these methods suffer from both false positive and false negative reports, and the candidates identified with different methods are often inconsistent with each other. We propose that a biological cause of this problem can be population subdivision, and a technical cause can be incomplete... Читать дальше...
by Sahand Khakabimamaghani, Dujian Ding, Oliver Snow, Martin Ester
Cancer is driven by genetic mutations that dysregulate pathways important for proper cell function. Therefore, discovering these cancer pathways and their dysregulation order is key to understanding and treating cancer. However, the heterogeneity of mutations between different individuals makes this challenging and requires that cancer progression is studied in a subtype-specific way. To address this challenge, we provide a mathematical model... Читать дальше...
by Andrew A. Bridges, Bonnie L. Bassler
Vibrio cholerae possesses multiple quorum-sensing (QS) systems that control virulence and biofilm formation among other traits. At low cell densities, when QS autoinducers are absent, V. cholerae forms biofilms. At high cell densities, when autoinducers have accumulated, biofilm formation is repressed, and dispersal occurs. Here, we focus on the roles of two well-characterized QS autoinducers that function in parallel. One autoinducer, called cholerae autoinducer-1 (CAI-1)... Читать дальше...
by Laetitia G. E. Wilkins, Matthieu Leray, Aaron O’Dea, Benedict Yuen, Raquel Peixoto, Tiago J. Pereira, Holly M. Bik, David A. Coil, J. Emmett Duffy, Edward Allen Herre, Harilaos Lessios, Noelle M. Lucey, Luis C. Mejia, Douglas B. Rasher, Koty Sharp, Emilia M. Sogin, Robert W. Thacker, Rebecca Vega Thurber, William T. Wcislo, Elizabeth G. Wilbanks, Jonathan A. Eisen
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Tesla’s sales in the U.S. have recently dropped after the tax credits halved in July, but the models on offer from Elon Musk’s electric vehicle (EV) maker are undisputedly the best-selling electric cars in America. All of Tesla’s models accounted for 75 percent of all U.S. sales of electric vehicles in October 2019, and for 77.7 percent between January and October, CleanTechnica’s Zachary Shahan has estimated, based on data from CleanTechnica and from automakers. Last month, the best selling EV... Читать дальше...
Europe is quickly becoming one of the most important export destinations for gas exporters. Production is decreasing quickly due to political and technical developments. The next few decades are promising for exporters. Nord Stream 2 is arguably one of the most contentious projects currently under development. Denmark recently granted the last necessary permit to start construction activities in its EEZ and analysts now agree that the project’s completion is only a matter of time. In reality, the... Читать дальше...
From a family board game night to a final trip to the garden, a heartwarming program that fulfills the dying wishes of ICU patients is finding success in other hospitals in North America, according to new research out of Ontario.
There's a few downs, but ultimately, VW has produced once again
The latest report card on how we are doing as a country to reduce emissions is in — and we’re not doing well
Allegations by the former COO points to political meddling in high profile cases
The historic port city of Wilmington, N.C., is finally recognizing one of the most consequential moments in its history—a white supremacist-led insurrection—for what it was: a coup.
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Matthew Petti
Security, Middle East
Huge trouble for the Crown Prince.
Key point: Saudi Arabia has not been able to quickly win or achieve its objectives.
Something is rotten in the Kingdom of Saudi Arabia. Prince Mohammad bin Salman, also known as MbS, was once the promising young face of the Arab monarchy. Now he’s racking up foreign-policy defeats abroad—and facing disturbing murmurs at home.
Over the weekend, Houthi rebels took down a Saudi-mechanized column along the border with Yemen... Читать дальше...
Nurse missed his first six coach's challenges then finally got one right during the Raptors' win over the Lakers.
Karl Fitzpatrick believes the Lions tour Down Under has been a missed opportunity on all fronts
To say that YouTubers have an uneasy relationship with the company that hosts their videos would be a massive understatement. It’s not uncommon for YouTube to demonetize videos with little in the way of explanation and, as a recent terms of service update reminded users, it can also just straight up remove videos and…
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A week after signing 16-year-old defender Casey Walls to a homegrown contract, the Earthquakes announced Monday the signing of 14-year-old goalkeeper Emmanuel Ochoa.
This is a preview of the Fintech Disruptors from the East research report from Business Insider Intelligence. 14-Day Risk Free Trial: Get full access to this and all Fintech industry research reports. Over the past 15 years, spending in China has become increasingly powered by mobile payments. In Q4 2018, China's third-party mobile payments industry was estimated to be worth 47.2 trillion yuan ($6.8 trillion) per Analysys, as cited by TechNode. This eclipsed the country's total retail sales for all of 2018... Читать дальше...
CBA has notched up a first quarter profit of $2.3 billion, saying profit margins would continue to come under pressure from very low interest rates.
Senior officials at the U.S. State Department said Monday the situation in Bolivia is not a coup, despite what some Latin American governments have claimed. Bolivia's first indigenous president Evo Morales resigned Sunday after weeks of protests following a disputed election. The U.S. officials said the Bolivian military merely pointed out the fact that public security had deteriorated by the time they asked Morales to resign.
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Ant & Dec's DNA Journey took Ant McPartlin and Declan Donnelly to New York tonight.