Thrombolysis in acute ischaemic stroke - time for a rethink?

In the US the licence, or marketing authorisation, for alteplase is limited to 0-3 hours after onset of stroke, but some other countries - including the UK and Australia - have extended the licence to 4.5 hours.

In an analysis article on thebmj.com Brian Alper, vice president of evidence based medicine research and development at Dynamed, and...