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Новости за 20.07.2019

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Poly-ADP-ribose assisted protein localization resolves that DJ-1, but not LRRK2 or α-synuclein, is localized to the mitochondrial matrix

Plos.org 
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by Nelson Osuagwu, Christian Dölle, Charalampos Tzoulis

Several proteins linked to familial Parkinson disease have been associated with mitochondrial (dys-)function and have been described to reside within mitochondria. The putative mitochondrial and sub-mitochondrial localization of these proteins remains disputed, however, potentially due to conflicting results obtained by diverging technical approaches. Using the high-resolution poly-ADP-ribose assisted protein localization assay that... Читать дальше...

Multi-scale modeling of the circadian modulation of learning and memory

Plos.org 
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by Shiju S, K. Sriram

We propose a multi-scale model to explain the time-of-day effects on learning and memory. We specifically model the circadian variation of hippocampus (HC) dependent long-term potentiation (LTP), depression (LTD), and the fear conditioning paradigm in amygdala. The model we built has both Goodwin type circadian gene regulatory network (GRN) and the conductance model of Morris-Lecar (ML) type to explain the spontaneous firing patterns (SFR) in suprachiasmatic nucleus (SCN). Читать дальше...



Binding affinities of human IgG1 and chimerized pig and rabbit derivatives to human, pig and rabbit Fc gamma receptor IIIA

Plos.org 
En

by Maryam M. Bhatti, Allen G. Cai, Jan-Willem Theunissen

While pigs and rabbits are used as models for human immune diseases, FcγR binding is poorly characterized in both test species. To evaluate antibody binding to FcγRIIIA, a receptor involved in antibody-dependent cellular cytotoxicity, chimerized antibodies were generated by grafting the variable regions of a human IgG1 onto scaffolds from both species. The affinities of the parent and chimeric antibodies to the FcγRIIIA proteins from all three species were determined. Читать дальше...

Functional association of Loc1 and Puf6 with RNA helicase Dhh1 in translational regulation of Saccharomyces cerevisiae Ste12

Plos.org 
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by Daehee Jung, Jong Seok Seo, Jayoung Nam, Jinmi Kim

Loc1 and Puf6, which are localized predominantly to the nucleus, are required for the localization and translational repression of the ASH1 mRNA in the yeast, Saccharomyces cerevisiae. During its transport to the daughter cell, the ASH1 mRNA is translationally repressed via associations with She2, Loc1, and Puf6. Here, we investigated the roles of Loc1 and Puf6 in the translation of mRNAs other than that encoding ASH1. In loc1 or puf6 deletion strains... Читать дальше...

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Москва

За прошедшую неделю подмосковные росгвардейцы обеспечили безопасность более 200 мероприятий



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Людмила Самсонова

Людмила Самсонова не отдала голландскую траву // Она продолжила серию российских побед на теннисном турнире в Хертогенбосе






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