by Elisa Gómez-Gil, Alejandro Franco, Marisa Madrid, Beatriz Vázquez-Marín, Mariano Gacto, Jesualdo Fernández-Breis, Jero Vicente-Soler, Teresa Soto, José Cansado
by Anna Peters, Petra Krumbholz, Elisabeth Jäger, Anna Heintz-Buschart, Mehmet Volkan Çakir, Sven Rothemund, Alexander Gaudl, Uta Ceglarek, Torsten Schöneberg, Claudia Stäubert
by Shi-You Jiang, Jing-Jie Tang, Xu Xiao, Wei Qi, Suqian Wu, Chao Jiang, Jiaxu Hong, Jianjiang Xu, Bao-Liang Song, Jie Luo
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by Takashi Nagashima, Yuichi Iino, Masahiro Tomioka
The avoidance of starvation is critical for the survival of most organisms, thus animals change behavior based on past nutritional conditions. Insulin signaling is important for nutritional state-dependent behavioral plasticity, yet the underlying regulatory mechanism at the cellular level remains unclear. Previous studies showed that insulin-like signaling is required for taste avoidance learning, in which the nematode Caenorhabditis elegans... Читать дальше...
by Sergey Ivanov, Alexey Lagunin, Dmitry Filimonov, Vladimir Poroikov
Adverse drug effects (ADEs) are one of the leading causes of death in developed countries and are the main reason for drug recalls from the market, whereas the ADEs that are associated with action on the cardiovascular system are the most dangerous and widespread. The treatment of human diseases often requires the intake of several drugs, which can lead to undesirable drug-drug interactions (DDIs), thus causing an increase in the frequency and severity of ADEs. Читать дальше...
by James J. Bull, Scott L. Nuismer, Rustom Antia
Replicating recombinant vector vaccines consist of a fully competent viral vector backbone engineered to express an antigen from a foreign transgene. From the perspective of viral replication, the transgene is not only dispensable but may even be detrimental. Thus vaccine revertants that delete or inactivate the transgene may evolve to dominate the vaccine virus population both during the process of manufacture of the vaccine as well as during the course of host infection. Читать дальше...
by Benjamin Merkt, Friedrich Schüßler, Stefan Rotter
Neurons in different layers of sensory cortex generally have different functional properties. But what determines firing rates and tuning properties of neurons in different layers? Orientation selectivity in primary visual cortex (V1) is an interesting case to study these questions. Thalamic projections essentially determine the preferred orientation of neurons that receive direct input. But how is this tuning propagated though layers,... Читать дальше...
by Anne Richelle, Chintan Joshi, Nathan E. Lewis
To gain insights into complex biological processes, genome-scale data (e.g., RNA-Seq) are often overlaid on biochemical networks. However, many networks do not have a one-to-one relationship between genes and network edges, due to the existence of isozymes and protein complexes. Therefore, decisions must be made on how to overlay data onto networks. For example, for metabolic networks, these decisions include (1) how to integrate gene expression levels using gene-protein-reaction rules... Читать дальше...
by David Zwicker
The olfactory system faces the difficult task of identifying an enormous variety of odors independent of their intensity. Primacy coding, where the odor identity is encoded by the receptor types that respond earliest, might provide a compact and informative representation that can be interpreted efficiently by the brain. In this paper, we analyze the information transmitted by a simple model of primacy coding using numerical simulations and statistical descriptions. We show... Читать дальше...
by Elizabeth A. Proctor, David D. Mowrey, Nikolay V. Dokholyan
Exposure to the environmental toxin β-methylamino-L-alanine (BMAA) is linked to amyotrophic lateral sclerosis (ALS), but its disease-promoting mechanism remains unknown. We propose that incorporation of BMAA into the ALS-linked protein Cu,Zn superoxide dismutase (SOD1) upon translation promotes protein misfolding and aggregation, which has been linked to ALS onset and progression. Using molecular simulation and predictive energetic computation... Читать дальше...
by Hye-Yeoung Yun, Min Wook Kim, Hye Seon Lee, Wantae Kim, Ji Hye Shin, Hyunmin Kim, Ho-Chul Shin, Hwangseo Park, Byung-Ha Oh, Won Kon Kim, Kwang-Hee Bae, Sang Chul Lee, Eun-Woo Lee, Bonsu Ku, Seung Jun Kim
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by Caitlin M. Braitsch, D. Berfin Azizoglu, Yadanar Htike, Haley R. Barlow, Ulrike Schnell, Christopher P. Chaney, Thomas J. Carroll, Ben Z. Stanger, Ondine Cleaver
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by Rémi Denise, Sophie S. Abby, Eduardo P. C. Rocha
Processes of molecular innovation require tinkering and shifting in the function of existing genes. How this occurs in terms of molecular evolution at long evolutionary scales remains poorly understood. Here, we analyse the natural history of a vast group of membrane-associated molecular systems in Bacteria and Archaea—the type IV filament (TFF) superfamily—that diversified in systems involved in flagellar or twitching motility, adhesion, protein secretion, and DNA uptake. Читать дальше...
The Champions League holders face their toughest pre-season test yet when they meet their manager's former club in Indiana
MARVEL STUDIOS are expected to unveil a range of new projects this weekend at SDCC. But what and when?
TEHRAN (FNA)- The Islamic Revolution Gauds Corps (IRGC) has released footage captured by an Iranian drone flying over the Strait of Hormuz and monitoring the US warships, including USS Boxer, belying a claim by Washington that the unmanned aircraft was shot down by the American forces. [VIDEO]
So brace yourself. It’s coming and you may not like the way it turns out. But then again, you might. Because it’s going to be different this time, right? The club is going to take on millions in salary to avoid having to trade their best prospects. Or to avoid trading too many of them. Right?
Following is the transcript of the video.
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| Video: Saadet Partisi'nden dikkat çeken FETÖ paylaşımı Saadet Partisi'nin sosyal medya hesapları üzerinden yapılan bir video dikkat çekti. Dünden bugüne FETÖ ile ilgili bilgilerin hatırlatıldığı videolarda AKP'li isimlerin açıklamalarına da yer verildi. |
| Foto Galeri: 20 Temmuz 2019 / Günün Karikatürü / Emre ULAŞ 20 Temmuz 2019 / Günün Karikatürü / Emre ULAŞ |
| Satacak bir şey kalmayınca halkın cebine göz diktiler |