by Philippe Jean-Luc Gradidge, Daleen Casteleijn, António Palmeira, Ralph Maddison, Catherine E. Draper
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by Dai Hatakeyama, Nozomi Chikamoto, Kanta Fujimoto, Takashi Kitahashi, Etsuro Ito
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by Ana Francisca Teixeira Gomes, Wendjilla Fortunato de Medeiros, Gerciane Silva de Oliveira, Isaiane Medeiros, Juliana Kelly da Silva Maia, Ingrid Wilza Leal Bezerra, Grasiela Piuvezam, Ana Heloneida de Araújo Morais
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by Claudia Mettke-Hofmann
Animals regularly scan their environment for predators and to monitor conspecifics. However, individuals in a group seem to differ in their vigilance linked to age, sex or state with recent links made to personality. The aims of the study were to investigate whether a) individuals differ consistently in their vigilance, b) vigilance is linked to other personality traits and c) other factors affect vigilance in the colour polymorphic Gouldian finch. Birds were tested... Читать дальше...
by Anna Kufner, Huma Fatima Ali, Martin Ebinger, Jochen B. Fiebach, David S. Liebeskind, Matthias Endres, Bob Siegerink, on behalf of the VISTA-Endovascular Collaborators
by Maykon Tavares de Oliveira, Carlos Alessandro Fuzo, Maria Cláudia da Silva, Eduardo Antônio Donadi, João Santana da Silva, Henrique Turin Moreira, André Schmidt, José Antônio Marin-Neto
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by Isac Rodrigues Comia, Regina Daniel Miambo, Emília Virgínia Noormahomed, Manuel Mahoche, Alberto Pondja, Robert Turner Schooley, Constance Benson, Jahit Sacarlal
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by Wilma A. Stolk, Luc E. Coffeng, Fatorma K. Bolay, Obiora A. Eneanya, Peter U. Fischer, T. Déirdre Hollingsworth, Benjamin G. Koudou, Aboulaye Méité, Edwin Michael, Joaquin M. Prada, Rocio M. Caja Rivera, Swarnali Sharma, Panayiota Touloupou, Gary J. Weil, Sake J. de Vlas
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by Leonard Koolman, Reenesh Prakash, Yohane Diness, Chisomo Msefula, Tonney S. Nyirenda, Franziska Olgemoeller, Paul Wigley, Blanca Perez-Sepulveda, Jay C. D. Hinton, Siân V. Owen, Nicholas A. Feasey, Philip M. Ashton, Melita A. Gordon
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by Kamonwan Chamchoy, Sirapapha Sudsumrit, Thanyapit Thita, Srivicha Krudsood, Rapatbhorn Patrapuvich, Usa Boonyuen
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by Andrew Ziesel, Qixuan Weng, Jasvinder S. Ahuja, Abhishek Bhattacharya, Raunak Dutta, Evan Cheng, G. Valentin Börner, Michael Lichten, Nancy M. Hollingsworth
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by Özlem Sarikaya Bayram, Özgür Bayram, Betim Karahoda, Cindy Meister, Anna M. Köhler, Sabine Thieme, Nadia Elramli, Dean Frawley, Jamie McGowan, David A. Fitzpatrick, Kerstin Schmitt, Leandro Jose de Assis, Oliver Valerius, Gustavo H. Goldman, Gerhard H. Braus
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by Mariann Eilertsen, David W. P. Dolan, Charlotte M. Bolton, Rita Karlsen, Wayne I. L. Davies, Rolf B. Edvardsen, Tomasz Furmanek, Harald Sveier, Herve Migaud, Jon Vidar Helvik
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by Lavisha Parab, Sampriti Pal, Riddhiman Dhar
Noise in expression of individual genes gives rise to variations in activity of cellular pathways and generates heterogeneity in cellular phenotypes. Phenotypic heterogeneity has important implications for antibiotic persistence, mutation penetrance, cancer growth and therapy resistance. Specific molecular features such as the presence of the TATA box sequence and the promoter nucleosome occupancy have been associated with noise. However, the... Читать дальше...
by Richard H. Baker, André Corvelo, Cheryl Y. Hayashi
The evolutionary diversification of orb-web weaving spiders is closely tied to the mechanical performance of dragline silk. This proteinaceous fiber provides the primary structural framework of orb web architecture, and its extraordinary toughness allows these structures to absorb the high energy of aerial prey impact. The dominant model of dragline silk molecular structure involves the combined function of two highly repetitive, spider-specific... Читать дальше...
by Martin Jankowiak, Fritz H. Obermeyer, Jacob E. Lemieux
The global effort to sequence millions of SARS-CoV-2 genomes has provided an unprecedented view of viral evolution. Characterizing how selection acts on SARS-CoV-2 is critical to developing effective, long-lasting vaccines and other treatments, but the scale and complexity of genomic surveillance data make rigorous analysis challenging. To meet this challenge, we develop Bayesian Viral Allele Selection (BVAS), a principled and scalable... Читать дальше...
by Nils Kalbfuß, Alexander Strohmayr, Marcel Kegel, Lien Le, Friederike Grosse-Holz, Barbara Brunschweiger, Katharina Stöckl, Christian Wiese, Carina Franke, Caroline Schiestl, Sophia Prem, Shuyao Sha, Katrin Franz-Oberdorf, Juliane Hafermann, Marc Thiemé, Eva Facher, Wojciech Palubicki, Cordelia Bolle, Farhah F. Assaad
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by Sahar Aghakhani, Sylvain Soliman, Anna Niarakis
Rheumatoid Arthritis (RA) is an autoimmune disease characterized by a highly invasive pannus formation consisting mainly of Synovial Fibroblasts (RASFs). This pannus leads to cartilage, bone, and soft tissue destruction in the affected joint. RASFs’ activation is associated with metabolic alterations resulting from dysregulation of extracellular signals’ transduction and gene regulation. Deciphering the intricate mechanisms at the origin... Читать дальше...
by Ashalatha Sreshty Mamidi, Avadhesha Surolia
The fundamental question on the mechanism of molecular recognition during ligand binding has attracted a lot of scientific scrutiny. The two competing theories of ligand binding–“induced fit” and “conformational selection” have been proposed to explain biomolecular recognition. Since exploring a family of proteins with similar structural architectures and conserved functional roles can provide valuable insight into the significance of molecular structure and function... Читать дальше...
by Yogita Sharma, Jared B. Bennett, Gordana Rašić, John M. Marshall
Close-kin mark-recapture (CKMR) methods have recently been used to infer demographic parameters such as census population size and survival for fish of interest to fisheries and conservation. These methods have advantages over traditional mark-recapture methods as the mark is genetic, removing the need for physical marking and recapturing that may interfere with parameter estimation. For mosquitoes, the spatial distribution... Читать дальше...
by Philip E. Bourne, Eli J. Draizen, Cameron Mura
Does reductionism, in the era of machine learning and now interpretable AI, facilitate or hinder scientific insight? The protein ribbon diagram, as a means of visual reductionism, is a case in point. Does the visual reductionism of the protein ribbon diagram facilitate or hinder scientific insight? In this Perspective, Philip Bourne encourages a reevaluation of its value in an era of machine learning and AI.
by William R. L. Anderegg, Anna T. Trugman, Jonathan Wang, Chao Wu
Nature-based climate solutions (NbCS) hold promise, but must be based on the best available science to be successful. We outline key ingredients of open data and science crucial for robust and scalable nature-based climate solutions efforts, as an urgent call to action for academic researchers, nongovernmental organizations, government agencies, and private companies. Open data and science are crucial for robust and scalable nature-based climate solution efforts. Читать дальше...
As work continues to try to solve nurse and doctor shortages in the neighbouring Vancouver Island communities of Port Hardy and Port McNeill, an old idea has resurfaced: shut down one ER in the short-term and pool resources to keep the other one open.
Now that we’re into December you’re probably reaching the end of your Christmas shopping list, with only a few “impossible to shop for” people left. We all have them — your dad, uncle, college-age cousin or eclectic neighbor — who are easy to procrastinate on because not only is the right gift for them a […]