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An allele-sharing, moment-based estimator of global, population-specific and population-pair FST under a general model of population structure

Plos.org 
En

by Jerome Goudet, Bruce S. Weir

Being able to properly quantify genetic differentiation is key to understanding the evolutionary potential of a species. One central parameter in this context is FST, the mean coancestry within populations relative to the mean coancestry between populations. Researchers have been estimating FST globally or between pairs of populations for a long time. More recently, it has been proposed to estimate population-specific FST values, and population-pair mean relative coancestry. Читать дальше...

Electrical synapse structure requires distinct isoforms of a postsynaptic scaffold

Plos.org 
En

by Jennifer Carlisle Michel, Margaret M. B. Grivette, Amber T. Harshfield, Lisa Huynh, Ava P. Komons, Bradley Loomis, Kaitlan McKinnis, Brennen T. Miller, Ethan Q. Nguyen, Tiffany W. Huang, Sophia Lauf, Elias S. Michel, Mia E. Michel, Jane S. Kissinger, Audrey J. Marsh, William E. Crow, Lila E. Kaye, Abagael M. Lasseigne, Rachel M. Lukowicz-Bedford, Dylan R. Farnsworth, E. Anne Martin, Adam C. Miller

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Efficient sex separation by exploiting differential alternative splicing of a dominant marker in Aedes aegypti

Plos.org 
En

by Shih-Che Weng, Igor Antoshechkin, Eric Marois, Omar S. Akbari

Only female mosquitoes consume blood giving them the opportunity to transmit deadly human pathogens. Therefore, it is critical to remove females before conducting releases for genetic biocontrol interventions. Here we describe a robust sex-sorting approach termed SEPARATOR (Sexing Element Produced by Alternative RNA-splicing of A Transgenic Observable Reporter) that exploits sex-specific alternative splicing of an innocuous... Читать дальше...

On convolutional neural networks for selection inference: Revealing the effect of preprocessing on model learning and the capacity to discover novel patterns

Plos.org 
En

by Ryan M. Cecil, Lauren A. Sugden

A central challenge in population genetics is the detection of genomic footprints of selection. As machine learning tools including convolutional neural networks (CNNs) have become more sophisticated and applied more broadly, these provide a logical next step for increasing our power to learn and detect such patterns; indeed, CNNs trained on simulated genome sequences have recently been shown to be highly effective at this task. Unlike previous approaches... Читать дальше...

The SKMT Algorithm: A method for assessing and comparing underlying protein entanglement

Plos.org 
En

by Arron Bale, Robert Rambo, Christopher Prior

We present fast and simple-to-implement measures of the entanglement of protein tertiary structures which are appropriate for highly flexible structure comparison. These are performed using the SKMT algorithm, a novel method of smoothing the Cα backbone to achieve a minimal complexity curve representation of the manner in which the protein’s secondary structure elements fold to form its tertiary structure. Its subsequent complexity is characterised... Читать дальше...

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ТАСС: задержанного за взятку генерала Муминджанова отправили в Москву


Biased placement of Mitochondria fission facilitates asymmetric inheritance of protein aggregates during yeast cell division

Plos.org 
En

by Gordon Sun, Christine Hwang, Tony Jung, Jian Liu, Rong Li

Mitochondria are essential and dynamic eukaryotic organelles that must be inherited during cell division. In yeast, mitochondria are inherited asymmetrically based on quality, which is thought to be vital for maintaining a rejuvenated cell population; however, the mechanisms underlying mitochondrial remodeling and segregation during this process are not understood. We used high spatiotemporal imaging to quantify the key aspects of mitochondrial dynamics... Читать дальше...

How effective were Australian Quarantine Stations in mitigating transmission aboard ships during the influenza pandemic of 1918-19?

Plos.org 
En

by Punya Alahakoon, Peter G. Taylor, James M. McCaw

The influenza pandemic of 1918-19 was the most devastating pandemic of the 20th century. It killed an estimated 50–100 million people worldwide. In late 1918, when the severity of the disease was apparent, the Australian Quarantine Service was established. Vessels returning from overseas and inter-state were intercepted, and people were examined for signs of illness and quarantined. Some of these vessels carried the infection throughout... Читать дальше...


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